Pectin-coated boron nitride nanotubes: In vitro cyto-/immune-compatibility on RAW 264.7 macrophages

Biochimica Et Biophysica Acta
Antonella RoccaGianni Ciofani

Abstract

Boron nitride nanotubes (BNNTs) represent a new opportunity for drug delivery and clinical therapy. The present work has the objective to investigate pectin-coated BNNTs (P-BNNTs) for their biocompatibility on macrophage cultures, since these cells are among the first components of the immune system to interact with administered nanoparticles. As first step, the potential toxicity of P-BNNTs is verified in terms of proliferation, oxidative stress induction and apoptosis/necrosis phenomena. Thereafter, the modulation of immune cell response following P-BNNT exposure is evaluated at gene and protein level, in particular focusing on cytokine release. Finally, P-BNNT internalization is assessed through transmission electron microscopy and confocal microscopy. The results proved that P-BNNTs are not toxic for macrophages up to 50 μg/ml after 24 h of incubation. The cytokine expression is not affected by P-BNNT administration both at gene and protein level. Moreover, P-BNNTs are internalized by macrophages without impairments of the cell structures. Collected data suggest that P-BNNTs cause neither adverse effects nor inflammation processes in macrophages. These findings represent the first and fundamental step in immune compatibilit...Continue Reading

References

Feb 1, 1997·Critical Reviews in Food Science and Nutrition·B R ThakurA K Handa
Nov 8, 2002·Biochimica Et Biophysica Acta·Michael U Martin, Holger Wesche
Aug 18, 1995·Science·N G ChopraA Zettl
Jan 24, 2008·Langmuir : the ACS Journal of Surfaces and Colloids·Nitish NairMichael S Strano
Nov 26, 2008·Nature Reviews. Immunology·David M Mosser, Justin P Edwards
Jan 6, 2009·Journal of the American Chemical Society·Xing ChenCarolyn R Bertozzi
Sep 17, 2009·Nanotechnology·Q HuangD Golberg
Dec 18, 2009·Endocrinology·Banu S ZolnikMarina A Dobrovolskaia
Nov 26, 2010·Journal of the Mechanical Behavior of Biomedical Materials·Debrupa LahiriArvind Agarwal
Feb 8, 2011·Biochimica Et Biophysica Acta·Jürgen SchellerStefan Rose-John
Apr 19, 2011·ACS Nano·Lenke HorváthBeat Schwaller
Sep 13, 2011·Journal of Hazardous Materials·Suxing GuiFashui Hong
Dec 20, 2011·International Journal of Pharmaceutics·Daniel Crístian Ferreira SoaresEdésia Martins Barros de Sousa
Apr 25, 2012·Journal of Molecular Recognition : JMR·C RoduitS Kasas
Jun 28, 2012·Swiss Medical Weekly·Bengt Fadeel
Sep 26, 2012·Colloids and Surfaces. B, Biointerfaces·Gianni CiofaniVirgilio Mattoli
Jan 30, 2013·International Journal of Pharmaceutics·Gianni CiofaniMario Giorgi
Oct 17, 2013·PloS One·Yekkuni L BalachandranSarvajeyakesavalu Suriyanarayanan
Jun 21, 2014·BioMed Research International·Qing JiaoQiu Zhang
Oct 24, 2014·Frontiers in Immunology·Guillermo Arango Duque, Albert Descoteaux
Feb 12, 2015·Beilstein Journal of Nanotechnology·Saban KalayMustafa Çulha
Apr 24, 2015·Applied Biochemistry and Biotechnology·Anna BarbaszJakub Barbasz
Jul 7, 2015·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Violet Aileen SenapatiAlok Dhawan
Jul 30, 2015·Colloids and Surfaces. B, Biointerfaces·Melis EmanetMustafa Çulha

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Citations

Dec 22, 2016·Nanomedicine·Ilaria PezziniGianni Ciofani
Jan 21, 2017·ACS Nano·Attilio MarinoGianni Ciofani
May 10, 2017·ACS Applied Materials & Interfaces·Attilio MarinoGianni Ciofani
Apr 19, 2017·Nanomaterials·Tiago H FerreiraEdesia M B Sousa
Jun 3, 2017·Biochimica Et Biophysica Acta. General Subjects·Özlem ŞenMustafa Çulha
Dec 5, 2019·Nanomedicine·Thaylice Cs CabralTiago H Ferreira
Jul 20, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Chee Huei LeeYoke Khin Yap
May 9, 2019·Expert Opinion on Therapeutic Patents·Karla S Romero-AguilarMarvin A Soriano-Ursúa
Apr 4, 2019·Daru : Journal of Faculty of Pharmacy, Tehran University of Medical Sciences·Tuğbagül Çal, Ülkü Ündeğer Bucurgat
Feb 20, 2021·Frontiers in Bioengineering and Biotechnology·Wancheng ChenYang Xiao
Mar 25, 2021·Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes·Hazel LinAlberto Bianco
Mar 27, 2021·Biomedical Materials·Sathyan Vivekanand Anandhan, Uma Maheswari Krishnan
Nov 24, 2021·The Journal of Physical Chemistry. B·Parham Khoshbakht MarviRouein Halladj

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