PMID: 19132237Jan 10, 2009Paper

Peculiar whole blood rotation thromboelastometry (Rotem) profile in 40 sideropenic anaemia patients

Thrombosis and Haemostasis
Luca SpieziaPaolo Simioni

Abstract

The ROtation ThromboElastoMetry analyser (ROTEM, Pentapharm, Munich, Germany) is useful for studying whole blood (WB) clot formation and lysis. Reduction of haematocrit (HCT) has been reported to influence traditional thromboelastography parameters without compromising "in vitro" blood coagulation. We performed this case-control study to evaluate ROTEM profiles in sideropenic anaemia patients with different degrees of reduction of HCT levels. Forty consecutively referred patients with sideropenic anaemia were enrolled. A group of 40 healthy age and gender matched subjects acted as a control. The influence of HCT on ROTEM was assessed in the study population and in a model of artificially reconstituted blood with modified HCT values. Cases presented significantly increased levels of maximum clot firmness (MCF) as compared to controls (p < 0.001) mimicking a sort of "hypercoagulable profile". However, thrombin generation tests failed to detect an increase in thrombin generation in cases as compared to controls. A statistically significant inverse linear correlation between HCT and MCF (p < 0.0001) was found. In addition, ROTEM profiles following "in vitro" manipulation of HCT confirmed the inverse linear correlation between HCT a...Continue Reading

Citations

Oct 26, 2010·Veterinary Clinical Pathology·Amir Kol, Dori L Borjesson
Aug 30, 2011·Transfusion Medicine Reviews·Daniel BolligerKenichi A Tanaka
Oct 13, 2009·Journal of Cardiothoracic and Vascular Anesthesia·Brady RumphKenichi A Tanaka
Oct 9, 2015·International Journal of Cardiology·Joanna Rupa-MatysekMieczysław Komarnicki
Dec 1, 2012·Journal of Veterinary Internal Medicine·C LiebenbergJ P Schoeman
Dec 20, 2011·Haemophilia : the Official Journal of the World Federation of Hemophilia·L SpieziaP Simioni
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Jul 11, 2013·The Veterinary Journal·A KolD L Borjesson
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Sep 14, 2016·Transfusion Medicine Reviews·Brittney WilliamsKenichi A Tanaka
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Jan 23, 2017·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Alberto ZanettoPaolo Simioni
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Apr 3, 2012·Anesthesia and Analgesia·Satoru OgawaKenichi A Tanaka
May 2, 2014·Anesthesia and Analgesia·Anna AgrenGustaf Edgren
Jan 15, 2020·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Luca SpieziaPaolo Simioni
Nov 15, 2019·Anesthesia and Analgesia·Marco RanucciEkaterina Baryshnikova
Feb 15, 2013·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Vadim KostousovNena Matijevic

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