PMID: 19916905Nov 18, 2009Paper

Peculiarities of abzymes from sera and milk of healthy donors and patients with autoimmune and viral diseases

Biochemistry. Biokhimii︠a︡
G A Nevinsky, V N Buneva

Abstract

The detection of catalytic activity of antibodies is the earliest indicator of development of autoimmune diseases (AID). In early stages of AID, the repertoire of abzymes with various properties is relatively small, but it is greatly increased during their development. Catalytic diversity of the abzymes includes DNase, RNase, ATPase, and oxidoreductase activities; there are antibodies phosphorylating proteins, lipids, and polysaccharides. This review summarizes new data on abzyme heterogeneity and possible reasons for this phenomenon. A possible role of abzymes and their exceptional multiplicity in the pathogenesis of different AID is discussed.

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Citations

Nov 16, 2011·Biochemistry. Biokhimii︠a︡·M A KrasnorutskiiG A Nevinsky
Apr 16, 2013·Biochemistry. Biokhimii︠a︡·V N BunevaG A Nevinsky
Feb 17, 2011·Immunotherapy·Carima AndradyKerry A Chester
Mar 25, 2016·Nature Reviews. Rheumatology·Philip W NobleJames E Hansen
May 7, 2015·Journal of Molecular Recognition : JMR·Anna S TolmachevaGeorgy A Nevinsky

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