Peculiarities of live cells' interaction with micro- and nanoparticles

Advances in Colloid and Interface Science
A S DukhinT G Gruzina

Abstract

Experimental evidence collected more than 20 years ago in different laboratories suggests that the interactions between live biological cells and micro- and nanoparticles depend on their metabolic state. These experiments were conducted by reputable groups, led by prominent leaders such as H. Pohl of the USA, who was the inventor of dielectrophoresis, and B. Derjaguin of the Soviet Union who was the leading author of DLVO theory. The experiments had been mostly conducted with microparticles in the early 1980s. In the early 1990s, Ukrainian researchers showed that the interaction of live cells with gold nanoparticles consisted of an initial reversible step that also depended on cell metabolism. They found indirect evidence that the ion pumps of the cells were responsible for the reversible step. Ion pumps generate a transmembrane potential, a measurable and widely-used characteristic of the cell's energetic state. The transmembrane potential, in turn, strongly affects the zeta-potential, as was experimentally discovered 40 years ago by several independent groups using cell electrophoresis. This relationship should be taken into account when DLVO theory is considered as the basis for describing the interactions between live cells...Continue Reading

References

Feb 15, 1979·European Journal of Biochemistry·L Wojtczak, M J Nałecz
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Aug 25, 2004·Langmuir : the ACS Journal of Surfaces and Colloids·Sharon L WalkerMenachem Elimelech
Jan 1, 1989·Microbial Ecology·M C van LoosdrechtA J Zehnder

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Citations

Jan 9, 2013·Langmuir : the ACS Journal of Surfaces and Colloids·Gregory G WolkenEdgar A Arriaga
Sep 11, 2012·Journal of Colloid and Interface Science·Rafael RoaEmilio Ruiz-Reina
Aug 17, 2011·Bio Systems·Qiuquan GuoJun Yang

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