PEDF regulates osteoclasts via osteoprotegerin and RANKL

Biochemical and Biophysical Research Communications
Toru AkiyamaPeter F M Choong

Abstract

Bone homeostasis is maintained through a balance between bone formation and resorption. Bone resorption is mainly carried out by a specific type of cell called the osteoclast (OCL). Previously, expression of pigment epithelium-derived factor (PEDF), the most potent endogenous inhibitor of angiogenesis, has been demonstrated in bone tissue and it known to induce differentiation in osteoblastic cells. Furthermore, therapeutic effects of PEDF on osteosarcoma, a prevalent primary bone tumor, with inhibition of bone destruction has been shown. Thus, PEDF is possibly involved in bone homeostasis as an inhibitor of bone resorption. To address this involvement, we studied the effect of PEDF on OCL function. OCL differentiation, RANKL-mediated survival and bone resorption activity were inhibited by PEDF in a dose-dependent manner. PEDF upregulated osteoprotegerin (OPG), which naturally blocks OCL maturation, in primary osteoblasts and OCL precursor cells. These results suggest that PEDF inhibits OCL function via regulating OPG expression, and thereby contributes to the maintenance of bone homeostasis.

References

Sep 1, 1991·Experimental Eye Research·J Tombran-TinkL V Johnson
Aug 5, 1998·Proceedings of the National Academy of Sciences of the United States of America·S HiratsukaM Shibuya
Sep 2, 1998·Proceedings of the National Academy of Sciences of the United States of America·R K JainE Keshet
Aug 3, 2002·Nature Reviews. Cancer·Gregory R Mundy
Sep 19, 2002·The Journal of Biological Chemistry·Christina MeyerS Patricia Becerra
Nov 19, 2004·Calcified Tissue International·Gerald M Y QuanPeter F M Choong
Sep 2, 2005·Biological Procedures Online·Toru AkiyamaSakae Tanaka
Jun 3, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jun CaiMike Boulton
Aug 8, 2006·Molecular Cancer Therapeutics·Eugene T H EkPeter F M Choong
Oct 25, 2007·PloS One·Naohiro KawamuraHiroshi Kawaguchi
Dec 20, 2007·Molecular Cancer Therapeutics·Crispin R Dass, Peter F M Choong
Sep 29, 2009·Trends in Molecular Medicine·Matthew L BroadheadPeter F M Choong

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Citations

Jun 8, 2012·Journal of Biomedicine & Biotechnology·Mina ElahyCrispin R Dass
Mar 21, 2013·Investigative Ophthalmology & Visual Science·Vasanthy VigneswaraZubair Ahmed
Jan 14, 2011·Clinical Interventions in Aging·Anne-Priscille Trouvin, Vincent Goëb
Sep 27, 2014·Orphanet Journal of Rare Diseases·Heike Hoyer-KuhnOliver Semler
Jun 13, 2012·Journal of Biomedicine & Biotechnology·Vijay Chandolu, Crispin R Dass
Nov 7, 2015·Lancet·Antonella Forlino, Joan C Marini
Jul 14, 2012·American Journal of Medical Genetics. Part C, Seminars in Medical Genetics·Marianne Rohrbach, Cecilia Giunta
Nov 25, 2011·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Giacomo VenturiFranco Antoniazzi
Aug 10, 2011·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Erica P HomanBrendan Lee
Mar 31, 2012·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Xin LiShmuel Yaccoby
Apr 25, 2012·American Journal of Medical Genetics. Part a·Tracy TuckerFrank Rauch
Nov 23, 2011·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Emily L Germain-Lee
Feb 13, 2014·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Charles R FarberJoan C Marini
Sep 12, 2014·The Journal of Pharmacy and Pharmacology·Oktay TacarCrispin R Dass
Mar 1, 2011·American Journal of Human Genetics·Jutta BeckerChristian Netzer
May 18, 2016·International Journal of Molecular Sciences·Shengcheng YaoKaijin Guo
Nov 1, 2016·Calcified Tissue International·Jian-Yi WangMei Li
Nov 5, 2016·American Journal of Medical Genetics. Part C, Seminars in Medical Genetics·Ronit MaromBrendan Lee
Aug 19, 2017·Nature Reviews. Disease Primers·Joan C MariniOliver Semler
Oct 17, 2017·Oncotarget·Xibo LiuLirong Chen
Apr 30, 2016·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Glenn S BelinskyChuhan Chung
Jul 7, 2018·The Journal of Pharmacy and Pharmacology·Mia Baxter-Holland, Crispin R Dass
Nov 27, 2020·Cancers·Naomi BrookArun Dharmarajan
Feb 9, 2020·Experimental Cell Research·Naomi BrookCrispin R Dass
Sep 28, 2020·Cellular Signalling·Julia EtichFrank Zaucke
Jul 21, 2021·Archives of Endocrinology and Metabolism·Mariana Lima Mascarenhas MoreiraFrancisco José Albuquerque de Paula

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