Pediatric adrenocortical neoplasms: can imaging reliably discriminate adenomas from carcinomas?

Pediatric Radiology
Kelsey A FlyntElaine M Caoili

Abstract

There is a paucity of literature describing and comparing the imaging features of adrenocortical adenomas and carcinomas in children and adolescents. To document the CT and MRI features of adrenocortical neoplasms in a pediatric population and to determine whether imaging findings (other than metastatic disease) can distinguish adenomas from carcinomas. We searched institutional medical records to identify pediatric patients with adrenocortical neoplasms. Pre-treatment CT and MRI examinations were reviewed by two radiologists in consensus, and pertinent imaging findings were documented. We also recorded relevant histopathological, demographic, clinical follow-up and survival data. We used the Student's t-test and Wilcoxon rank sum test to compare parametric and nonparametric continuous data, and the Fisher exact test to compare proportions. We used receiver operating characteristic (ROC) curve analyses to evaluate the diagnostic performances of tumor diameter and volume for discriminating carcinoma from adenoma. A P-value ≤0.05 was considered statistically significant. Among the adrenocortical lesions, 9 were adenomas, 15 were carcinomas, and 1 was of uncertain malignant potential. There were no differences in mean age, gender ...Continue Reading

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Citations

Dec 17, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Xin Yu, Zheng Li
Nov 6, 2018·Pediatric Surgery International·Zuopeng WangShan Zheng
Sep 21, 2019·Abdominal Radiology·Abdelrahman K HanafyAjaykumar C Morani
Feb 9, 2017·Journal of Pediatric Endocrinology & Metabolism : JPEM·Andréa Farias de Melo-LeiteJorge Elias
Nov 27, 2019·International Journal of Pediatric Endocrinology·Eman Abdalla Ali ElnawMohamed Ahmed Abdullah
Oct 12, 2017·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Kiran M SargarRebecca Hulett Bowling

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