Pediatric B-Cell Lymphoma With Lymphoblastic Morphology, TdT Expression, MYC Rearrangement, and Features Overlapping With Burkitt Lymphoma

Pediatric Blood & Cancer
Jessica MeznarichZeinab Afify

Abstract

Burkitt lymphoma (BL) and B-lymphoblastic lymphoma are subtypes of pediatric non-Hodgkin lymphoma with different presenting features, treatment, and outcomes. This case report documents a 5-year-old female who presented with B-cell lymphoma with lymphoblastic morphology, terminal deoxynucleotidyl transferase expression, MYC rearrangement, and features overlapping with BL. Genomic microarray analysis identified a gain on the long arm of chromosome 1 without other definitive changes. She was treated according to a BL protocol and remains in remission 16-months after initial diagnosis.

References

Nov 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·L PegoraroC M Croce
Mar 1, 1996·Leukemia & Lymphoma·I SlavutskyM Eppinger
Mar 9, 2007·Nature·Charles G MullighanJames R Downing
Nov 10, 2009·Blood·Anthony V MoormanStephen J Proctor
Aug 26, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Véronique Minard-ColinCatherine Patte

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Citations

Oct 13, 2017·Leukemia & Lymphoma·Chuer Zhang, Gladstone Austin Amos Burke
Apr 16, 2019·Cytopathology : Official Journal of the British Society for Clinical Cytology·Jinnan LiXueying Su

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