Pediatric central nervous system vascular malformations

Pediatric Radiology
Ezra A Burch, Darren B Orbach

Abstract

Pediatric central nervous system (CNS) vascular anomalies include lesions found only in the pediatric population and also the full gamut of vascular lesions found in adults. Pediatric-specific lesions discussed here include infantile hemangioma, vein of Galen malformation and dural sinus malformation. Some CNS vascular lesions that occur in adults, such as arteriovenous malformation, have somewhat distinct manifestations in children, and those are also discussed. Additionally, children with CNS vascular malformations often have associated broader vascular conditions, e.g., PHACES (posterior fossa anomalies, hemangioma, arterial anomalies, cardiac anomalies, eye anomalies and sternal anomalies), hereditary hemorrhagic telangiectasia, and capillary malformation-arteriovenous malformation syndrome (related to the RASA1 mutation). The treatment of pediatric CNS vascular malformations has greatly benefited from advances in endovascular therapy, including technical advances in adult interventional neuroradiology. Dramatic advances in therapy are expected to stem from increased understanding of the genetics and vascular biology that underlie pediatric CNS vascular malformations.

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Citations

Jun 17, 2016·Interventional Neuroradiology : Journal of Peritherapeutic Neuroradiology, Surgical Procedures and Related Neurosciences·Jinlu YuZhongxue Wu
Nov 1, 2018·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Pradeep GoyalBalasubramanya Kolar
Mar 29, 2019·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Pradeep GoyalRajiv Mangla
Feb 14, 2020·The New England Journal of Medicine·Alice W NewtonGrace Linder
Apr 17, 2021·Pediatric Radiology·Frederic BertinoC Matthew Hawkins

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