Pediatric cerebellar astrocytoma: a review

Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery
Christopher M Bonfield, Paul Steinbok

Abstract

Cerebellar astrocytomas (CA) are one of the most common posterior fossa tumors in children. The vast majority is low grade, and prognosis for long-term survival is excellent. Recent literature about CA was reviewed to provide an up to date overview of the epidemiology, pathology, molecular and cell biology, diagnosis, presentation, management, and long-term outcomes. Surgical resection remains the first-line treatment with complete removal of the tumor the goal. However, even when only subtotal resection has been achieved, there is a significant chance that the tumor will remain stable or will regress spontaneously. Adjuvant chemotherapy is reserved for those tumors that progress despite surgery, and more personalized chemotherapy is being pursued with better understanding of the molecular genetics of this tumor. Radiotherapy has generally not been recommended, but stereotactic radiotherapy and conformal proton beam radiotherapy may be reasonable options in the setting of relapse or progression. In the long term, permanent neurologic deficits, mainly cerebellar dysfunction, are common, but quality of life and cognitive function are generally good. Low-grade CA remains primarily a surgical disease, with excellent survival rates....Continue Reading

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Citations

May 5, 2016·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Thora GudrunardottirUNKNOWN Iceland Delphi Group
Sep 24, 2016·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·D ChieffoC Di Rocco
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Jul 8, 2021·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·H HartleyR Kumar
Aug 7, 2021·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Frederik GrossePablo Hernáiz Driever

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