Pediatric clinical pharmacology studies in Chagas disease: focus on Argentina.

Paediatric Drugs
Facundo García-BournissenGideon Koren

Abstract

Chagas disease is a neglected parasitic disease endemic in the Americas. It mainly affects impoverished populations and the acute phase of the infection mostly affects children. Many cases have also been detected in nonendemic countries as a result of recent migratory trends. The chronic phase is relatively asymptomatic, but 30% of patients with chronic infection eventually develop cardiac and digestive complications that commonly lead to death or disability. Only two drugs are available for the treatment of Chagas disease, benznidazole and nifurtimox. These drugs have been shown to be effective in the treatment of both acute and early chronic phases in children, but the pharmacokinetics of these drugs have never been studied in this population. We have set out to conduct a pharmacokinetics study of benznidazole in a pediatric population with Chagas disease. The results of this study are expected to allow better estimation of the optimal doses and schedule of pharmacotherapy for Chagas disease in children.

References

Oct 1, 1977·Journal of Pharmacokinetics and Biopharmaceutics·L B SheinerV V Marathe
Nov 1, 1992·Journal of Clinical Microbiology·G RussomandoK Morita
Nov 1, 1992·Clinical Pharmacokinetics·A H LauL H Danziger
Jan 1, 1992·Annual Review of Pharmacology and Toxicology·L B Sheiner, T M Ludden
Jan 1, 1992·European Journal of Clinical Pharmacology·G González-MartinJ Paredes
Jan 1, 1990·Chemico-biological Interactions·R Docampo
Jun 1, 1986·Arquivos de neuro-psiquiatria·C R DefariaA Rassi
Sep 1, 1984·British Journal of Cancer·P WorkmanP R Twentyman
Feb 1, 1981·Journal of Pharmacokinetics and Biopharmaceutics·L B SheinerL A Pagliaro
Sep 1, 1995·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·H Freilij, J Altcheh
Sep 1, 1997·Journal of the Neurological Sciences·C L Flores-Vieira, A A Barreira
Sep 1, 1997·Journal of the Neurological Sciences·C L Flores-VieiraA A Barreira
Oct 28, 1998·The American Journal of Tropical Medicine and Hygiene·S Sosa EstaniC Yampotis
May 16, 2000·Revista Do Instituto De Medicina Tropical De São Paulo·D Fabbro De SuasnábarN Amicone
Nov 13, 2001·Clinical and Experimental Pharmacology & Physiology·S B Duffull
Jan 21, 2003·Emerging Infectious Diseases·Ricardo E GürtlerJoel E Cohen
Aug 15, 2003·The Journal of Antimicrobial Chemotherapy·Alejandro G SchijmanHéctor Freilij
Oct 29, 2003·Trends in Parasitology·Julio A Urbina, Roberto Docampo
Sep 14, 2004·Revista Da Sociedade Brasileira De Medicina Tropical·Mirtha L StreigerNorberto A Amicone
Nov 15, 2005·Journal of Pharmacokinetics and Pharmacodynamics·Stephen DuffullJohn Eccleston
Dec 16, 2005·The AAPS Journal·Peter L Bonate
Dec 16, 2005·The AAPS Journal·Erik Olofsen, Albert Dahan
Dec 16, 2005·The AAPS Journal·Amit Roy, Ene I Ette
Dec 16, 2005·The AAPS Journal·Bernd MeibohmJeffrey S Barrett
Oct 31, 2006·Memórias do Instituto Oswaldo Cruz·Antonio R L TeixeiraNancy R Sturm
Nov 1, 2006·Current Opinion in Infectious Diseases·Sergio Sosa-Estani, Elsa Leonor Segura

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Citations

Jul 16, 2013·Therapeutic Drug Monitoring·María E MarsonGuido Mastrantonio
Aug 11, 2010·Expert Review of Anti-infective Therapy·Inés OliveiraJoaquim Gascon
Apr 5, 2016·Parasitology·María C FabrizioNorberto J Bartoloni
Apr 9, 2014·European Journal of Drug Metabolism and Pharmacokinetics·María Elena MarsonGuido Enrique Mastrantonio
May 8, 2015·PLoS Neglected Tropical Diseases·Lauren PullJean-Yves Siriez
Sep 24, 2009·Memórias do Instituto Oswaldo Cruz·Sergio Sosa-EstaniElsa Leonor Segura
Dec 15, 2020·British Journal of Clinical Pharmacology·Fernanda LascanoJaime Altcheh
Nov 11, 2020·Antimicrobial Agents and Chemotherapy·A J BerensteinJ Altcheh

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