Pediatric combined heart-liver transplantation performed en bloc: a single-center experience

Pediatric Transplantation
Amy L HillWaldo Concepcion

Abstract

Pediatric CHLT is rarely performed in transplant centers and even fewer are performed en bloc. In the hands of an experienced surgeon with the appropriate patient selection, CHLT performed en bloc may have several operative and immunologic benefits, thereby resulting in improved outcomes for the transplant recipient. A single-institutional, retrospective review from 1/1/06 to 12/31/10 was conducted. Three pediatric patients with end-stage heart and liver disease who were considered low immunologic risk were included. All were managed by the same surgeon with a herein-described CHLT donor and recipient operation. Data were collected on patient and graft survival, rejection episodes, infectious complications, operative time, intraoperative transfusion requirements, and immunosuppression regimens. One-yr patient and graft survival rates were 100%. No patients experienced antibody-mediated or cell-mediated rejection. No patients had postoperative infections, and all patients were free of opportunistic infections at one-yr post-transplant. All patients were maintained safely on steroid-free immunosuppression. There were no intraoperative complications. In pediatric end-stage heart and liver disease patients with low immunologic risk...Continue Reading

References

Jun 28, 2008·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Helen S TeDonald M Jensen

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Citations

Apr 15, 2014·Seminars in Thoracic and Cardiovascular Surgery. Pediatric Cardiac Surgery Annual·Anees J Razzouk, Leonard L Bailey
Feb 19, 2013·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Seth A HollanderDaniel Bernstein
Sep 27, 2015·Current Treatment Options in Cardiovascular Medicine·Elisa BradleyCurt Daniels
Jul 13, 2016·Paediatric Anaesthesia·Manchula NavaratnamChandra Ramamoorthy
Aug 17, 2016·Transplantation Reviews·Eliza W BealSylvester M Black
Aug 20, 2016·Journal of Pediatric Gastroenterology and Nutrition·Sylvia Ofei, Cheryl Gariepy
Oct 16, 2015·World Journal for Pediatric & Congenital Heart Surgery·Sarah A TeeleNikhil K Chanani
Mar 21, 2019·Clinical Transplantation·Sumeet S VaikunthGeorge K Lui
Jan 25, 2021·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Danielle SgangaSharon Chen
Jun 2, 2021·BMJ Case Reports·Andrew D ShubinMalcolm MacConmara
Jun 14, 2021·Pediatric Transplantation·Swati ChoudhrySusan W Denfield
Aug 16, 2021·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Sharon ChenDanielle Sganga
Jan 2, 2021·Journal of Cardiothoracic and Vascular Anesthesia·Alan M SmeltzHarendra Arora
Jan 16, 2020·Annals of Surgery·Nicolas A BrozziRodrigo M Vianna

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