Pediatric cutaneous mastocytosis and c-KIT mutation screening

Allergy and Asthma Proceedings
Aysegul ErtugrulSerap Ozmen

Abstract

Background: Cutaneous mastocytosis (CM) is a heterogeneous disease that commonly presents with skin lesions in childhood. Objective: In this study, we aimed to evaluate the clinical and laboratory test results of our patients with CM to ascertain prognostic factors by using patients' long-term follow-up results and to determine c-KIT (receptor tyrosine kinase) mutation from peripheral blood samples, which might be responsible for the etiopathogenesis of pediatric mastocytosis. Methods: The clinical observation data of 32 children who had been diagnosed with CM were retrospectively researched. Exon 8, 9, 11, 13, and 17 c-KIT gene locations were analyzed from DNA material that was obtained from peripheral blood samples of all the patients by using polymerase chain reaction analysis and automatic DNA sequencing. Results: The tryptase level was higher in patients with familial cases and in cases of patients who had gastrointestinal mediator releasing symptoms (p = 0.017, p = 0.038, respectively). The use of clarithromycin and the use of vitamin D were determined as triggers for mediator release. Hypogammaglobulinemia was found in six patients (18.8%). Indoor tobacco exposure was seen to be higher in patients not in remission than i...Continue Reading

Citations

May 22, 2019·Digestive Diseases and Sciences·Anas GremidaDenis McCarthy
Sep 27, 2019·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·Gaolei ZhangXingjia Wang
Jul 22, 2020·Current Opinion in Pediatrics·Sadaf H Hussain
Jan 26, 2021·American Journal of Clinical Dermatology·Julie V Schaffer
Apr 28, 2021·International Journal of Dermatology·Justyna CzarnyMagdalena Lange
May 1, 2021·Journal of Clinical Medicine·Florica SandruRaluca-Gabriela Miulescu
May 19, 2021·Journal of Pediatric Hematology/oncology·Arzu Yazal ErdemEmine Dibek Misirlioğlu

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