Pediatric gastritis and peptic ulcer disease

Indian Journal of Pediatrics
U BleckerB D Gold

Abstract

Inflammation of the gastric and duodenal mucosa is the end result of an imbalance between mucosal defensive and aggressive factors. The degree of inflammation and imbalance between defensive and aggressive factors can then result in varying degrees of gastritis and/or mucosal ulceration. Gastritis and ulcers of the duodenum or stomach can be classified as primary or secondary. The majority of children with chronic gastritis and ulcers in the stomach or duodenum have secondary inflammation or mucosal ulceration. These secondary ulcers generally occur due to a systemic condition like head trauma or overwhelming sepsis, or as sequelae to drug ingestion (i.e. non-steroidal anti-inflammatory agents), but secondary gastroduodenal ulcers can also occur in specific disease conditions such as Zollinger-Ellison syndrome or Crohn's disease. In almost all children with primary duodenal or gastric ulcers mucosal inflammation and, less frequently, ulceration is caused by a spiral shaped, gram-negative, microaerobic rod Helicobacter pylori. Recent epidemiological evidence has linked chronic H. pylori infection with the development of gastric carcinomas.

References

May 1, 1992·Journal of Pediatric Gastroenterology and Nutrition·G PrietoS Carrasco
Sep 1, 1990·Journal of Clinical Pathology·G OderdaN Ansaldi
Feb 8, 1990·The New England Journal of Medicine·B DrummP M Sherman
May 1, 1988·Journal of Pediatric Gastroenterology and Nutrition·P F Whitington, G L Whitington
Jun 1, 1987·Archives of Disease in Childhood·G L Toms, R Scott
Feb 12, 1987·The New England Journal of Medicine·J I IsenbergM A Koss
Apr 15, 1985·The Medical Journal of Australia·B J MarshallR J Glancy
Mar 1, 1974·Annals of Internal Medicine·N SynderW Hughes
Sep 15, 1983·The New England Journal of Medicine·H J De AizpuruaB H Toh
Apr 1, 1995·Annals of the Rheumatic Diseases·M GazarianR M Laxer
Aug 1, 1993·Journal of Pediatric Gastroenterology and Nutrition·R O OccenaR J Sokol
Mar 1, 1996·Brain and Cognition·O Godefroy, M Rousseaux
Aug 1, 1996·Journal of General Internal Medicine·W E SmalleyW A Ray
Nov 1, 1996·Postgraduate Medicine·S P Pearson, I Kelberman

Citations

Mar 22, 2006·The Consultant Pharmacist : the Journal of the American Society of Consultant Pharmacists·James W Cooper, William E Wade

Related Concepts

Gastritis
Marginal Ulcer

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