Pediatric Hodgkin Lymphoma Treated at Cancer Institute, Chennai, India: Long-Term Outcome

Journal of Global Oncology
Venkatraman RadhakrishnanTenali Gnana Sagar

Abstract

Pediatric Hodgkin lymphoma (HL) is a highly curable malignancy. Outcomes for pediatric HL may vary between developed and developing countries for multiple reasons. This study was conducted to ascertain the outcomes of children with HL at our center and to identify risk factors for recurrent disease. We analyzed the outcomes of 172 consecutive, previously untreated patients with pediatric HL presenting at our center from 2001 to 2010. Patients were treated with either adriamycin, bleomycin, vinblastine, and dacarbazine or adriamycin, bleomycin, vinblastine, cyclophosphamide, vincristine, prednisone, and procarbazine chemotherapy initially, and radiation to bulky sites or a single site of residual disease when appropriate. The median duration of follow-up was 77 months. The median age of the patients was 10 years; 127 (74%) of the 172 patients were male. The extent of disease was stage I and II in 59% of the patients. B symptoms were present in 32% of the patients, and 27% had bulky disease. The most common histologic subtype was mixed cellularity (45%). The 5-year overall survival (OS) and progression-free survival (PFS) of the entire cohort were 92.9% and 83.1%, respectively. The 5-year OS rates for patients with stage I, II, I...Continue Reading

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Citations

Dec 14, 2019·Journal of Global Oncology·Arun SeshachalamHemant Deepak Shewade
Mar 31, 2017·Indian Journal of Pediatrics·Venkatraman RadhakrishnanSameer Bakhshi
Feb 9, 2020·Cancer Epidemiology·Shuvadeep GangulySameer Bakhshi
Jun 17, 2021·South Asian Journal of Cancer·Maneya PadmaS Chennagiri Premalata
Jul 23, 2021·Pediatric Blood & Cancer·Amita MahajanJagdish Chandra

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Methods Mentioned

BETA
biopsy
bone

Software Mentioned

SPSS
SPSS Statistics

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