Pediatric Inflammatory and Autoimmune Neurologic Disorders at a Tertiary Medical Center.

Journal of Child Neurology
Angela M CurcioWendy S Vargas

Abstract

To describe the spectrum of pediatric inflammatory neurologic diseases and compare the sensitivity of ancillary testing for these diagnoses. We analyzed clinical features and outcomes of 98 children with an immune-mediated central nervous system disorder. We compared sensitivities of each diagnostic modality. We identified the following diagnoses: acute cerebellar ataxia (n = 14; 14.3%), acute demyelinating encephalomyelitis (n = 13; 13.3%), multiple sclerosis (MS) (n = 18; 18.4%), anti-N-methyl-d-aspartate receptor encephalitis (anti-NMDAR encephalitis) (n = 15; 15.3%), encephalitis not otherwise specified (n = 12; 12.2%), and "Other" (n = 26; 26.5%). "Other" included acute transverse myelitis, neuromyelitis optica, central nervous system lupus, primary central nervous system vasculitis, Rasmussen encephalitis, opsoclonus myoclonus ataxia syndrome, and clinically isolated syndrome. The mean age of onset of all diagnoses was 7.9 ± 5.5 years. The diagnostic sensitivity of magnetic resonance imaging (MRI) for acute demyelinating encephalomyelitis and multiple sclerosis was 92.3% and 94.4%, respectively. Cerebrospinal fluid was sensitive for multiple sclerosis in 92.3%, where 75% of patients had cerebrospinal fluid oligoclonal ban...Continue Reading

References

Aug 12, 2009·Annals of Neurology·Nicole R FloranceJosep Dalmau
Feb 4, 2010·Neurology·D ChabasUNKNOWN US Network of Pediatric MS Centers of Excellence
May 21, 2013·Pediatric Neurology·Harry T WhelanStephen Ashwal
Apr 25, 2015·Neurology. Neuroimmunology and Neuroinflammation·Sandra BigiSusanne M Benseler
Jun 22, 2018·Nature Reviews. Neurology·Elizabeth WellsUNKNOWN attendees of the International Neuroimmune Meeting

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