Pediatric lipid reference values in the general population: The Dutch lifelines cohort study

Journal of Clinical Lipidology
Jan W BalderJan A Kuivenhoven

Abstract

Atherosclerosis starts in childhood and its progression is influenced by lifelong low-density lipoprotein cholesterol (LDL-c) exposure, the so-called cholesterol burden. Early identification of children and adolescents with severely elevated LDL-c is thus of major clinical significance. This is especially true for children with familial hypercholesterolemia (FH), a frequent but undertreated genetic disorder. To identify children with possible FH, insight in the distribution of lipid levels in children is a prerequisite. To provide health care professionals with contemporary age- and gender-based pediatric reference values for lipid and lipoprotein levels to help the identification of children with dyslipidemia, especially FH. Lifelines is a large prospective population-based Dutch cohort study. Children from 8 till 18 years of age were included and fasting lipid levels were measured. Smoothed reference curves and percentiles (5th, 10th, 25th, 50th, 75th, 90th, and 95th) were generated using the Generalized Additive Models for Location, Scale and Shape package in the statistical software R. A total of 8071 children (3823 boys and 4248 girls) were included. In the total cohort we noted marked dynamic changes in lipid and lipoprot...Continue Reading

Citations

Dec 4, 2019·Acta Neuropsychiatrica·Katrin Tomson-JohansonJaanus Harro
Dec 20, 2019·Clinical Chemistry and Laboratory Medicine : CCLM·Michel R LangloisUNKNOWN European Atherosclerosis Society (EAS) and the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM) Join
Nov 20, 2020·Arteriosclerosis, Thrombosis, and Vascular Biology·Antoine RimbertMathilde Di Filippo
Mar 8, 2021·The International Journal of Behavioral Nutrition and Physical Activity·Hester Jaspers Faijer-WesterinkTanja G M Vrijkotte
Apr 13, 2021·Netherlands Heart Journal : Monthly Journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation·N S NurmohamedL F Reeskamp
Aug 15, 2020·Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation·Hjørdis ThorsteinsdottirAnna Bjerre

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