PMID: 11906639Mar 22, 2002Paper

Pediatric liver transplantation in metabolic disease: clinical decision making

Pediatric Transplantation
Benjamin L Shneider

Abstract

Proper utilization of liver transplantation in the management of pediatric metabolic diseases requires a comprehensive understanding of both metabolic disease and the risk and benefits of transplantation. This brief review focuses on issues that pertain to the treatment of tyrosinemia type I, bile acid biosynthesis disorders, primary hyperoxaluria, Crigler-Najjar Type I, and mitochondrial diseases. These entities are used as prototypes to illustrate many of the principles that are applied in a more general sense to the management of metabolic diseases. The natural history of these disorders are considered in the context of the risks of liver transplantation. Indications, contraindications, and both current and future alternatives to transplantation, are considered.

References

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Citations

Aug 19, 2014·World Journal of Gastroenterology : WJG·Cédric MaerckxEtienne Sokal
Apr 14, 2015·Pediatric Gastroenterology, Hepatology & Nutrition·Jun Suk KimSung-Gyu Lee
Jan 1, 2003·World Journal of Gastroenterology : WJG·Yan-Ling YangKai-Zong Li
Feb 14, 2006·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·K A StraussD H Morton
Oct 11, 2005·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Daisuke MoriokaKoichi Tanaka
Jun 25, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·M Thamara P R PereraPatrick J McKiernan
Apr 25, 2008·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Keli Hansen, Simon Horslen
Apr 2, 2015·Human Gene Therapy·Pasquale Piccolo, Nicola Brunetti-Pierri
Oct 14, 2004·Annals of Tropical Paediatrics·S N Joshi, P Venugopalan
Jun 11, 2004·Journal of Inherited Metabolic Disease·A B Burlina
Apr 3, 2008·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Keli Hansen, Simon Horslen
Nov 13, 2008·Pediatric Transplantation·Scott M SutherlandWaldo Concepcion
Jun 10, 2006·Journal of Inherited Metabolic Disease·Markus Grompe
Dec 13, 2005·Molecular Therapy : the Journal of the American Society of Gene Therapy·Pascal van der WegenBob J Scholte

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