Abstract
Diagnosis and treatment of primary lung adenocarcinoma in children remains challenging given its rarity. Here we highlight the clinical history, pathological evaluation, genomic findings, and management of a very young patient with metastatic lung adenocarcinoma. A 10-year-old white girl presented with brain metastases due to primary pulmonary adenocarcinoma. Next generation sequencing analysis with "Comprehensive Cancer Panel" highlighted the presence of multiple non-targetable mutations in the FLT4, UBR5, ATM, TAF1, and GUCY1A2 genes. She was treated aggressively with chemotherapy, surgery, and radiation therapy for local and distant recurrence. Eventually, therapy with nivolumab was started compassionately, and she died 23 months after diagnosis. Extremely rare cancers in children such as lung adenocarcinoma need accurate and specific diagnosis in order to develop an optimal plan of treatment. It is also necessary to underline that "children are not little adults," thus implying that an adult-type cancer in the pediatric population might have a different etiopathogenesis. Diagnostic confirmation and primary treatment of such rare conditions should be centralized in reference centers, collaborative networks, or both, with mul...Continue Reading
References
Apr 1, 1992·Clinical Pediatrics·A Dosanjh
Jan 1, 1989·Medical and Pediatric Oncology·D M Epstein, J M Aronchick
Jul 1, 1983·The Annals of Thoracic Surgery·G E Hartman, S J Shochat
Sep 1, 1993·Journal of Pediatric Surgery·B J HancockP P Collin
Aug 1, 1996·Journal of Neurology, Neurosurgery, and Psychiatry·C E CounsellR Grant
Aug 21, 2002·Pediatric Hematology and Oncology·Mehmet KantarHüdaver Alper
Feb 17, 2005·Pediatric Blood & Cancer·Dave R LalMichael P La Quaglia
Oct 20, 2006·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Andrea FerrariUNKNOWN Associazione Italiana Ematologia Oncologia Pediatrica (AIEOP)
Dec 26, 2007·Seminars in Pediatric Surgery·Christopher B Weldon, Robert C Shamberger
Apr 9, 2008·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Jeong-A ParkThad T Ghim
Sep 8, 2009·The Journal of Pediatrics·Naoki UchisakaTomohiro Morio
Jul 14, 2010·Journal of Pediatric Surgery·David C YuChristopher B Weldon
Oct 27, 2010·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Mark L KaytonMarc Ladanyi
Mar 8, 2011·Cell·Douglas Hanahan, Robert A Weinberg
Mar 27, 2012·Medical Oncology·Achuta K Guddati, Creticus P Marak
Dec 25, 2012·Expert Review of Anticancer Therapy·Andrea FerrariUNKNOWN EXPeRT Board
Mar 31, 2015·Journal of Pediatric Surgery·Yesenia RojasJed G Nuchtern
Apr 8, 2015·The Lancet Oncology·Matthew G OserJeffrey A Engelman
Aug 21, 2015·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·William D TravisUNKNOWN WHO Panel
Sep 4, 2015·PloS One·Yuehong WangJianying Zhou
Feb 10, 2016·Asian Cardiovascular & Thoracic Annals·Reza AfghaniMona Rezapour Esfahani
Apr 12, 2016·Cancer·Priscila H GoncalvesShirish M Gadgeel
Nov 12, 2016·European Clinical Respiratory Journal·Ane Stillits MårengUffe Bodtger
Feb 19, 2017·Current Problems in Cancer·Rajiv KumarTimothy A Yap
Aug 23, 2017·Scientific Reports·Junjun WangYafei Li
Citations
Sep 2, 2020·BMC Cancer·Kumar SaurabhLevi J Beverly
Jan 10, 2021·Virchows Archiv : an International Journal of Pathology·Luisella RighiMauro Papotti
Feb 8, 2021·American Journal of Surgery·Nathan J SmithChandler S Cortina
Jun 12, 2021·Frontiers in Oncology·Xin LiXiaobing Shen