Pediatric lung adenocarcinoma presenting with brain metastasis: a case report

Journal of Medical Case Reports
Lucia De MartinoLucia Quaglietta

Abstract

Diagnosis and treatment of primary lung adenocarcinoma in children remains challenging given its rarity. Here we highlight the clinical history, pathological evaluation, genomic findings, and management of a very young patient with metastatic lung adenocarcinoma. A 10-year-old white girl presented with brain metastases due to primary pulmonary adenocarcinoma. Next generation sequencing analysis with "Comprehensive Cancer Panel" highlighted the presence of multiple non-targetable mutations in the FLT4, UBR5, ATM, TAF1, and GUCY1A2 genes. She was treated aggressively with chemotherapy, surgery, and radiation therapy for local and distant recurrence. Eventually, therapy with nivolumab was started compassionately, and she died 23 months after diagnosis. Extremely rare cancers in children such as lung adenocarcinoma need accurate and specific diagnosis in order to develop an optimal plan of treatment. It is also necessary to underline that "children are not little adults," thus implying that an adult-type cancer in the pediatric population might have a different etiopathogenesis. Diagnostic confirmation and primary treatment of such rare conditions should be centralized in reference centers, collaborative networks, or both, with mul...Continue Reading

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Citations

Jan 10, 2021·Virchows Archiv : an International Journal of Pathology·Luisella RighiMauro Papotti
Feb 8, 2021·American Journal of Surgery·Nathan J SmithChandler S Cortina
Jun 12, 2021·Frontiers in Oncology·Xin LiXiaobing Shen

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Methods Mentioned

BETA
X-ray
surgical resection
transfection
biopsy

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