Pediatric marginal donor hearts: Trends in US national use, 2005-2014

Pediatric Transplantation
Adam K MorrisonDeipanjan Nandi

Abstract

Pediatric patients awaiting heart transplant face high mortality rates due to donor organ shortages, including non-use of marginal donor hearts. We examined national trends in pediatric marginal donor heart use over time. UNOS data were queried for heart donors <18 years from 2005 to 2014. The proportion of donor hearts considered marginal was determined using previously cited marginal characteristics: left ventricular ejection fraction (LVEF) <50%, use of ≥2 inotropes, cerebrovascular death, CDC high-risk status, and eGFR < 30 mL/min/1.73 m2 . Disposition of donor hearts was determined and stratified by marginal donor status. Of 6778 pediatric hearts offered from 2005 to 2014, 2373 (35.0%) were considered marginal. Non-use of marginal donor hearts was significantly higher than that of donor hearts without any marginal characteristics (59.5% vs 20.3%, P < .001). In particular, LVEF < 50% and donor inotropes were associated with high rates of organ non-use among pediatric donors. Yet, non-use of marginal donor organs decreased from 67% to 48% from 2005 to 2014 (P < .001). Although the proportion of pediatric donor hearts used for pediatric patients has increased, more than half of donor hearts are declined for use in pediatric r...Continue Reading

References

Oct 22, 2008·Transplantation Proceedings·C I TsaoS S Wang
Nov 4, 2008·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·S V McDiarmidS C Sweet
May 26, 2009·The Annals of Thoracic Surgery·Leonard L BaileyRichard E Chinnock
Sep 29, 2009·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Douglas MahChristopher S D Almond
Nov 18, 2009·Transplantation Proceedings·A K SinghalJ Stehlik
May 14, 2010·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Alberto ForniGiuseppe Faggian
Apr 15, 2011·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Kimberly Y LinRobert Shaddy
Nov 19, 2011·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Eric S WeissAshish S Shah
Feb 9, 2013·Circulation. Heart Failure·Kiran K KhushBenjamin A Goldstein
May 8, 2013·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·R EasterwoodM E Richmond
Oct 10, 2013·Pediatric Transplantation·Jennifer ConwayUNKNOWN Pediatric Heart Transplant Study Investigators
Jul 20, 2014·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Raj SahuleeJoseph W Rossano
Dec 3, 2014·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Farhan ZafarDavid L S Morales
Aug 20, 2016·Transplant International : Official Journal of the European Society for Organ Transplantation·Asma M KhanRaj Sahulee
Apr 4, 2017·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Farhan ZafarDavid L S Morales
Apr 4, 2017·The Journal of Thoracic and Cardiovascular Surgery·Farhan ZafarDavid L Morales

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Citations

Mar 22, 2020·Pediatric Transplantation·Martin SchweigerAnne I Dipchand
Mar 22, 2020·Pediatric Transplantation·Susan W DenfieldOliver Miera
Mar 22, 2020·Pediatric Transplantation·Daniel ZimpferOliver Miera
Jun 28, 2019·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Christine S HwangMalcolm MacConmara
Dec 16, 2020·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Nicholas A SzugyeRyan A Moore
Feb 24, 2020·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Richard KirkWarren A Zuckerman
Oct 5, 2021·Medical Decision Making : an International Journal of the Society for Medical Decision Making·Alison E Butler, Gretchen B Chapman
Jul 30, 2019·The Journal of Thoracic and Cardiovascular Surgery·Kyle W RiggsFarhan Zafar
Aug 24, 2019·The Journal of Thoracic and Cardiovascular Surgery·Katsuhide Maeda, John C Dykes

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