Pediatric mastocytosis

Current Opinion in Pediatrics
Sadaf H Hussain

Abstract

The current article highlights recent developments in the field of pediatric cutaneous mastocytosis. Mastocytosis is a spectrum of conditions that range from fleetingly benign to aggressively malignant. Through recognizing the natural progression of disease, the role of biomarkers and mutational analysis, treatment and risk of triggers, physicians can confidently stage, counsel and manage patients with pediatric cutaneous mastocytosis. Many lesions of cutaneous mastocytosis are chronic with some resolving around the mid-teenage years. KIT mutations are found in the majority of pediatric cutaneous mastocytosis but are not correlated with prognosis. Serum tryptase levels may be elevated in pediatric cutaneous mastocytosis patients without systemic mastocytosis. Pimecrolimus, omalizumab and tyrosine kinase inhibitors are effective treatment options. The low risk of NSAIDs and vaccinations has been characterized and epinephrine autoinjectors are rarely utilized in the pediatric cutaneous mastocytosis patient. Pediatric cutaneous mastocytosis is a heterogeneous disease with good outcome overall. Organomegaly, elevated tryptase levels and the presence of KIT mutation in peripheral blood may aid in the decision to pursue bone marrow b...Continue Reading

References

Jun 19, 2010·International Archives of Allergy and Immunology·Zhongcai MaDavid Paek
Aug 4, 2010·Pediatric Dermatology·Hiroshi KogaSeigo Korematsu
Jun 6, 2015·The Journal of Allergy and Clinical Immunology·Melody C CarterDean D Metcalfe
Sep 28, 2017·Postȩpy dermatologii i alergologii·Magdalena LangeRoman Nowicki
Feb 17, 2018·Clinical and Experimental Dermatology·J D M HughesM Ben-Shoshan
Feb 21, 2018·Clinical and Experimental Dermatology·J MashiahA Kutz
Jun 23, 2018·Pediatric Dermatology·Hye-Jin AhnMu-Hyoung Lee
Jul 10, 2018·Pediatric Dermatology
Jul 17, 2018·Immunology and Allergy Clinics of North America·Almudena MatitoIván Alvarez-Twose
Nov 23, 2018·Current Pediatric Reviews·Alexander K C LeungKin Fon Leong
Jan 9, 2019·Postȩpy dermatologii i alergologii·Justyna CzarnyRoman J Nowicki
Mar 2, 2019·Allergy and Asthma Proceedings·Aysegul ErtugrulSerap Ozmen
Mar 5, 2019·Pediatric Dermatology·Helena A JenkinsonMoise L Levy
Jun 4, 2019·The Journal of Allergy and Clinical Immunology. in Practice·Mona M LiuManish J Butte
Jul 7, 2019·The Journal of Allergy and Clinical Immunology. in Practice·Emily A GurneeLeslie P Lawley
Aug 6, 2019·Expert Opinion on Pharmacotherapy·Mariarita LaforgiaGirolamo Ranieri

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Citations

Jan 26, 2021·American Journal of Clinical Dermatology·Julie V Schaffer
Apr 4, 2021·International Journal of Molecular Sciences·Knut BrockowPeter Valent
Apr 4, 2021·International Journal of Molecular Sciences·Magdalena LangePeter Valent
Sep 26, 2021·Pediatric Dermatology·Aysegul ErtugrulIlknur Bostanci

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