Pediatric melanoma and aggressive Spitz tumors: a retrospective diagnostic, exposure and outcome analysis

Translational Pediatrics
Kelly M BaileyRajen Mody

Abstract

The diagnosis and management of pediatric melanomas is challenging given the presence of both melanomas and histologically aggressive Spitz tumors of undetermined biological significance (S-UBS) in this age group. Study objectives were to examine: factors leading to diagnostic delays, therapy side effects and patient outcomes in these diagnostic groups. A retrospective case review was performed using The University of Michigan's pediatric oncology database over a 13-year timespan. Patients referred to our clinic for consideration of interferon therapy due to a diagnosis of a stage III melanoma or aggressive appearing S-UBS with significant lymph node involvement were included. We found two major causes of diagnosis delay: patients with amelanotic lesions misdiagnosed as having a wart and cases reviewed by non-expert pathologists upfront. The side effects from interferon therapy requiring dose adjustments included neutropenia, thrombocytopenia and mood disturbances. There was wide variability in surveillance scan utilization, therefore leading to variability in patient radiation exposure. Unlike melanoma patients, none of the S-UBS patients experienced disease progression or death. This study highlights the challenges with the i...Continue Reading

Citations

Jul 4, 2020·Current Opinion in Pediatrics·Danna MoustafaElena B Hawryluk
Mar 13, 2021·Surgical Oncology Clinics of North America·Jennifer H AldrinkMary Austin
Jun 3, 2020·Surgical Oncology Clinics of North America·Adrienne B ShannonGiorgos C Karakousis
Sep 28, 2021·Melanoma Research·Cristian FidanziGiovanni Bagnoni

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