Pediatric nonlymphoblastic non-Hodgkin lymphoma: baseline, interim, and posttreatment PET/CT versus contrast-enhanced CT for evaluation--a prospective study

Radiology
Sameer BakhshiArun Malhotra

Abstract

To prospectively examine the roles of positron emission tomography (PET)/computed tomography (CT) and conventional contrast material-enhanced CT at baseline, after two cycles of chemotherapy, and after completion of chemotherapy in pediatric patients with nonlymphoblastic non-Hodgkin lymphoma (NHL) who were treated with similar standard treatment protocols. The institutional ethics committee approved the study protocol, and all patients were enrolled after written informed consent was obtained. Patients with nonlymphoblastic NHL were prospectively enrolled between January 2008 and March 2010. Patients underwent contrast-enhanced CT and PET/CT for staging and for response assessment after two cycles of chemotherapy (interim) and treatment completion. Complete metabolic response versus no metabolic response at PET/CT and complete response versus no complete response at contrast-enhanced CT was analyzed by using Kaplan-Meier survival analysis. The final study included 34 patients with nonlymphoblastic NHL (median age, 10.5 years). Baseline PET/CT and contrast-enhanced CT showed concordance in depiction of 112 disease sites; PET/CT depicted 18 more disease sites and two fewer disease sites than contrast-enhanced CT (P = .0003). Dis...Continue Reading

References

Nov 5, 1997·The New England Journal of Medicine·M P LinkS B Murphy
Nov 24, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·B D ChesonG P Canellos
Dec 18, 2004·European Journal of Nuclear Medicine and Molecular Imaging·Gisele DepasRoland Hustinx
Apr 20, 2006·Pediatric Radiology·Miguel Hernandez-PampaloniAbass Alavi
Jul 18, 2006·Journal of Computer Assisted Tomography·Elka MillerEinat Even-Sapir
Oct 19, 2006·European Journal of Nuclear Medicine and Molecular Imaging·Zvi Bar-SeverOra Israel
Jan 24, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Bruce D ChesonUNKNOWN International Harmonization Project on Lymphoma
Apr 25, 2007·Leukemia & Lymphoma·Veronique EdelineSylvia Neuenschwander
Dec 14, 2007·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Teruhiko TerasawaHirokazu Nagai
Mar 4, 2008·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Ananth ShankarRoss Pinkerton
Aug 12, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Christian FurthPatrick Hundsdoerfer
Sep 17, 2009·European Journal of Nuclear Medicine and Molecular Imaging·Raef RiadHussein Abdel-Dayem

❮ Previous
Next ❯

Citations

Feb 13, 2014·European Journal of Nuclear Medicine and Molecular Imaging·Lale Kostakoglu, Bruce D Cheson
Dec 18, 2013·Seminars in Ultrasound, CT, and MR·Lauren W AverillMonica Epelman
Jan 22, 2013·Diagnostic and Interventional Imaging·B DupasS Le Gouill
May 3, 2016·Journal of the Egyptian National Cancer Institute·Hany Abdel RahmanEmad Moussa
May 5, 2016·European Journal of Radiology·Neha S KwatraEdward Y Lee
Jan 16, 2013·Acta Radiologica·Martin BiermannKaren Rosendahl
Mar 1, 2013·Acta Radiologica·Trond HagtvedtAlf Kolbenstvedt
Nov 2, 2018·The British Journal of Radiology·Greg ChambersAndrew Scarsbrook
Mar 4, 2014·Acta Radiologica·Trond HagtvedtTrond Mogens Aaløkken
Sep 7, 2018·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Arian Pourmehdi LahijiHeike Daldrup-Link
Jul 12, 2017·Current Radiology Reports·Heike Daldrup-Link
May 24, 2017·European Journal of Nuclear Medicine and Molecular Imaging·Julian KirchnerLale Umutlu
Jan 13, 2015·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Lebriz UsluHeike E Daldrup-Link

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.