Pediatric-onset multiple sclerosis is associated with reduced parental health-related quality of life and family functioning

Multiple Sclerosis : Clinical and Laboratory Research
Julia O'MahonyBrenda Banwell

Abstract

Diagnosis of multiple sclerosis (MS) during childhood has the potential to impact the affected child's self-perception and the health-related quality of life (HRQoL) of the family. To evaluate the impact of chronic disease, in children ascertained as having MS and their families, when compared to those with monophasic acquired demyelinating syndrome (monoADS). In a national prospective cohort study of pediatric acquired demyelinating syndromes (ADS), the HRQoL of children and their families was captured using the Pediatric Quality of Life Inventory (PedsQL™) Modules. Participants (58 MS; 178 monoADS) provided cross-sectional HRQoL data a median (interquartile range (IQR)) of 4.1 (2.0-6.0) years after disease onset. The HRQoL of parents of children with MS and their family functioning was lower when compared to that of parents and families of children with monoADS (both p < 0.001); parents of children with MS reported greater emotional dysfunction, worry, worse communication, and lower family functioning irrespective of clinical disease activity. Self-reports of the MS and monoADS participants did not suggest a difference in overall HRQoL or fatigue after adjusting for age of the child at the time of assessment. While children w...Continue Reading

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Jan 11, 2020·Neurology·Ruth Ann MarrieUNKNOWN Canadian Pediatric Demyelinating Disease Network
Aug 5, 2020·Developmental Medicine and Child Neurology·Morvwen DuncanCheryl Hemingway
Mar 27, 2021·Developmental Medicine and Child Neurology·Nikki OwNancy E Mayo
May 4, 2021·Developmental Medicine and Child Neurology·Anna EusebiStefano Sotgiu
Jun 3, 2021·International Journal of Environmental Research and Public Health·Johannes BoettcherHolger Zapf
Aug 28, 2021·International Journal of Environmental Research and Public Health·Slávka MroskováĽubomíra Tkáčová
Feb 8, 2022·Multiple Sclerosis : Clinical and Laboratory Research·Julia O'MahonyRuth Ann Marrie

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