Pediatric osteoarticular infections caused by Streptococcus pneumoniae before and after the introduction of the heptavalent pneumococcal conjugate vaccine.

European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology
C LemaîtreM Lorrot

Abstract

Streptococcus pneumoniae is an uncommon cause of osteoarticular infections (OAI) in children. The objective of this study was to investigate the clinical and laboratory characteristics of pneumococcal OAI before and after the introduction of the heptavalent pneumococcal conjugate vaccine (PCV7). Data were retrospectively collected from children aged <16 years who were hospitalized for pneumococcal OAI between 1997 and 2007 in four Parisian teaching hospitals. Forty-three children were included (32 with arthritis and 11 with osteomyelitis) and the median age of these children was 12.5 months (range 3 months to 14 years). Serotypes were available for 19/43 strains (44 %) from 1997 onwards and for 12/13 strains (92 %) from 2005 onwards. Seven unvaccinated children were infected with vaccine serotypes and we observed only one vaccine failure. After the introduction of PCV7, we noted an increase in short-term complications and the emergence of serotype 19A, which was penicillin-intermediate in 86 % of cases. After PCV7 introduction, serotype 19A was the most frequent serotype implicated in pediatric pneumococcal OAI. The 13-valent pneumococcal conjugate vaccine introduced in France in June 2010 should cover the emerging serotype.

References

Jan 1, 1991·American Journal of Diseases of Children·H Faden, M Grossi
Jan 1, 1991·American Journal of Diseases of Children·N M Jacobs
Mar 1, 1985·Clinical Pediatrics·I HadariS Moses
Feb 1, 1981·Clinical Pediatrics·M J Chusid, J R Sty
Feb 1, 1995·The Pediatric Infectious Disease Journal·I PochevilleJ L Hernandez
Jun 1, 1996·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·A P SirotnakJ D Klein
Apr 8, 1998·Journal of Pediatric Orthopedics·D W Lundy, D K Kehl
Apr 27, 2000·The Pediatric Infectious Disease Journal·H R Shinefield, S Black
Aug 23, 2000·Baillière's Best Practice & Research. Clinical Rheumatology·M G GavilánB S Artola
Sep 11, 2001·The Journal of Infectious Diseases·B Henriques NormarkG Källenius
Feb 13, 2002·The Pediatric Infectious Disease Journal·Sheldon L KaplanWilliam J Barson
Jan 23, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·John J RossDaniel S Shapiro
Apr 4, 2003·International Journal of Antimicrobial Agents·UNKNOWN Members of the SFM Antibiogram Committee
May 2, 2003·The New England Journal of Medicine·Cynthia G WhitneyUNKNOWN Active Bacterial Core Surveillance of the Emerging Infections Program Network
Jul 3, 2003·Pediatrics·Ekopimo O IbiaAndreas Pikis
Jul 24, 2003·Archives of Disease in Childhood·C C GrantD W Crook
Oct 18, 2003·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Sayomporn SirinavinPanida Wittayawongsruji
Nov 8, 2003·Journal of Clinical Microbiology·Angela B Brueggemann, Brian G Spratt
Dec 4, 2004·Journal of Pediatric Orthopedics. Part B·Ibrahim KaloucheFernand Dagher
Jan 25, 2005·The Pediatric Infectious Disease Journal·Katherine HsuUNKNOWN Massachusetts Department of Public Health Epidemiologists
Jan 26, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·François AngoulvantAlbert Faye
Aug 12, 2005·Acta Paediatrica·K MoumileA Ferroni
Sep 6, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Didier GuillemotClaude Carbon
Apr 7, 2006·The New England Journal of Medicine·Moe H KyawUNKNOWN Active Bacterial Core Surveillance of the Emerging Infections Program Network
Apr 13, 2006·JAMA : the Journal of the American Medical Association·Katherine A PoehlingWilliam Schaffner
Jul 10, 2008·Scandinavian Journal of Rheumatology·A PerezI Marimón
Sep 3, 2008·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·A LepoutreDaniel Lévy-Bruhl
Jan 1, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Sandra S RichterGary V Doern
Jun 24, 2009·Vaccine·Ron Dagan
Oct 13, 2009·The Pediatric Infectious Disease Journal·Maria A Carrillo-MarquezSheldon L Kaplan
Dec 2, 2009·The Journal of Infectious Diseases·Tamara PilishviliUNKNOWN Active Bacterial Core Surveillance/Emerging Infections Program Network
Feb 26, 2010·The Pediatric Infectious Disease Journal·Gal Dubnov-RazPablo Yagupsky
Sep 3, 2010·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Marie KempfPhilippe Lanotte
Feb 8, 2011·The Pediatric Infectious Disease Journal·Corinne LevyUNKNOWN Bacterial Meningitis Study Group
May 10, 2011·The Pediatric Infectious Disease Journal·Romain BasmaciStéphane Bonacorsi

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Citations

Oct 15, 2013·The Journal of Infection·Sheldon L Kaplan
Mar 14, 2013·Pediatric Clinics of North America·Markus Pääkkönen, Heikki Peltola
Apr 6, 2018·The Pediatric Infectious Disease Journal·María Belén Hernández-RupérezJesús Saavedra-Lozano
Jul 21, 2017·The Pediatric Infectious Disease Journal·Liset OlarteSheldon L Kaplan

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