Pediatric primary high-grade spinal glioma: a National Cancer Database analysis of current patterns in treatment and outcomes.

Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery
Ravi S NunnaAnkit I Mehta

Abstract

Pediatric primary high-grade spinal glioma (p-HGSG) is an extremely rare disease process, with little data within the current literature. Akin to primary high-grade gliomas, this cancer has been exemplified by dismal prognosis and poor response to modern treatment paradigms. This study seeks to investigate the current trends affecting overall survival using the National Cancer Database (NCDB). The NCDB was queried for p-HGSG between 2004 and 2016, by utilizing the designated diagnosis codes. Kaplan-Meier curves were generated, and log-rank testing was performed to analyze factors affecting overall survival. In addition, a Cox proportional-hazards model was used to perform multivariate regression analysis of survival outcomes. A cohort of 97 patients was identified with a histologically confirmed p-HGSG. The overall incidence of p-HGSG in all pediatric spinal cord tumors is 7.5%, with a mean survival time of 25.3 months (SD, 21.0) and 5-year overall survival of 17.0%. The majority of patients underwent surgery (n = 87, 89.7%), radiotherapy (n = 73, 75.3%), and chemotherapy (n = 60, 61.9%). Univariate, multivariate, and Kaplan-Meier log-rank testing failed to demonstrate an association between performing surgery, extent of resect...Continue Reading

References

Oct 1, 1979·Journal of Neurosurgery·A L DeSousaA Hockey
Nov 1, 1985·Journal of Neurosurgery·R Reimer, B M Onofrio
Dec 1, 1996·Journal of Neurosurgery·S ConstantiniF J Epstein
Mar 30, 2010·International Journal of Radiation Oncology, Biology, Physics·Rahul D TendulkarThomas E Merchant
Oct 4, 2011·Journal of Neuro-oncology·Birte WolffJohannes Ea Wolff
Sep 11, 2012·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Martin BeneschMaura Massimino
Feb 26, 2013·International Journal of Radiation Oncology, Biology, Physics·Zachary D GussStephanie A Terezakis
Dec 3, 2014·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Tezer KutlukMünevver Büyükpamukçu
Nov 5, 2016·Journal of Neurosurgery. Pediatrics·Subhas K KonarAnil Nanda
Mar 21, 2017·Acta Pharmacologica Sinica·Y RajeshMahitosh Mandal
Aug 1, 2018·Scientific Reports·Pouyan KheirkhahAnkit I Mehta
Jan 27, 2019·International Journal of Radiation Oncology, Biology, Physics·Daniel J IndelicatoJulie A Bradley
Apr 28, 2019·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Mohammed Ali AlviAditya Raghunathan
Jun 24, 2019·Trends in Immunology·Stacie Shiqi WangMisty Rayna Jenkins
Oct 4, 2019·European Journal of Translational Myology·Amin Alinezhad, Fatemeh Jafari

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