Pediatric Right Ventricular Cardiac Steatosis following Immunosuppressive Treatment

Fetal and Pediatric Pathology
Diana KozmanBahig M Shehata

Abstract

Background: Right ventricular myocardial fatty infiltration has been observed in pediatric cardiac allografts with an associated decrease in graft life expectancy. A possible explanation included an immunosuppressant drug effect which prompted us to examine common factors between non-cardiac transplanted immunosuppressed patients and postmortem hearts of pediatric patients who died of non-cardiac causes.Materials and Methods: Sixty-one of 1,030 pediatric autopsies were from immunosuppressed children who were treated with corticosteroids for malignant tumors, non-cardiac transplantations, or other chronic clinical conditions. 62 children who died for non-medical reasons served as controls. Cardiac H&E autopsy slides were examined for right ventricular fatty infiltration.Results: There was a significant increase in right ventricular fatty infiltration in patients that were non-cardiac transplanted and immunosuppressed compared to controls. None of the index patients had other features of arrhythmogenic right ventricular dysplasia.Conclusions: Immunosuppression may lead to right ventricular fatty infiltration in childhood.

References

Sep 28, 2005·Nature Clinical Practice. Cardiovascular Medicine·Gianluca IacobellisArya M Sharma
Dec 7, 2006·Annals of the New York Academy of Sciences·Brian R Walker, Ruth Andrew
Jul 29, 2010·Journal of Pediatric Endocrinology & Metabolism : JPEM·Pier Paolo BassareoGiuseppe Mercuro
Nov 11, 2010·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Jeffrey H SacksBahig M Shehata
Sep 7, 2011·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Y-H ChangM-Y Shiau
Jun 21, 2014·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Yanjun DongLiping Zhang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.