Pediatric Sepsis Definition-A Systematic Review Protocol by the Pediatric Sepsis Definition Taskforce.

Critical Care Explorations
Kusum MenonLauren R Sorce

Abstract

Sepsis is responsible for a substantial proportion of global childhood morbidity and mortality. However, evidence demonstrates major inaccuracies in the use of the term "sepsis" in clinical practice, coding, and research. Current and previous definitions of sepsis have been developed using expert consensus but the specific criteria used to identify children with sepsis have not been rigorously evaluated. Therefore, as part of the Society of Critical Care Medicine's Pediatric Sepsis Definition Taskforce, we will conduct a systematic review to synthesize evidence on individual factors, clinical criteria, or illness severity scores that may be used to identify children with infection who have or are at high risk of developing sepsis-associated organ dysfunction and separately those factors, criteria, and scores that may be used to identify children with sepsis who are at high risk of progressing to multiple organ dysfunction or death. We will identify eligible studies by searching the following databases: MEDLINE, Embase, and the Cochrane Central Register of Controlled Trials. We will include all randomized trials and cohort studies published between January 1, 2004, and March 16, 2020. Data extraction will include information rel...Continue Reading

References

May 1, 1984·European Journal of Obstetrics, Gynecology, and Reproductive Biology·H SchneiderA Huch
May 1, 1996·Critical Care Medicine·M M PollackU E Ruttimann
Jan 24, 2003·Intensive Care Medicine·Anthony SlaterUNKNOWN Paediatric Index of Mortality (PIM) Study Group
Mar 29, 2003·Intensive Care Medicine·Mitchell M LevyUNKNOWN International Sepsis Definitions Conference
Jan 8, 2005·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Brahm GoldsteinUNKNOWN International Consensus Conference on Pediatric Sepsis
Oct 5, 2006·Intensive Care Medicine·François LauzierOlivier Lesur
Jul 18, 2009·American Journal of Respiratory and Critical Care Medicine·Karen ChoongUNKNOWN Canadian Critical Care Trials Group
May 28, 2011·The New England Journal of Medicine·Kathryn MaitlandUNKNOWN FEAST Trial Group
Dec 16, 2011·Pediatrics International : Official Journal of the Japan Pediatric Society·Eleni A VolakliMaria Giala
May 15, 2012·Lancet·Li LiuUNKNOWN Child Health Epidemiology Reference Group of WHO and UNICEF
Feb 20, 2013·Annals of Internal Medicine·Jill A HaydenClaire Bombardier
Mar 4, 2015·American Journal of Respiratory and Critical Care Medicine·Scott L WeissUNKNOWN Sepsis Prevalence, Outcomes, and Therapies (SPROUT) Study Investigators and Pediatric Acute Lung Injury and Sepsis Investiga
May 20, 2015·Critical Care Medicine·Murray M PollackUNKNOWN Eunice Kennedy Shriver National Institute of Child Health and Human Development Collaborative Pediatric Critical Care Resear
Sep 17, 2015·Critical Care : the Official Journal of the Critical Care Forum·Scott L WeissUNKNOWN SPROUT Study Investigators and Pediatric Acute Lung Injury and Sepsis Investigators Network
Feb 24, 2016·JAMA : the Journal of the American Medical Association·Christopher W SeymourDerek C Angus
Feb 24, 2016·JAMA : the Journal of the American Medical Association·Mervyn SingerDerek C Angus
Mar 2, 2017·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·R Scott WatsonFolafoluwa O Odetola
Jun 29, 2017·The New England Journal of Medicine·Konrad ReinhartSimon Finfer
Mar 7, 2018·The Lancet. Respiratory Medicine·Carolin Fleischmann-StruzekNiranjan Kissoon
Sep 1, 2018·The Lancet Child & Adolescent Health·Philipp K A AgyemanUNKNOWN Swiss Pediatric Sepsis Study
Apr 30, 2019·Journal of Medical Internet Research·Nassr NamaJames Dayre McNally
Mar 4, 2020·Pediatric Research·Matthew McGovernUNKNOWN Infection, Inflammation, Immunology and Immunisation (I4) section of the ESPR

❮ Previous
Next ❯

Citations

Nov 1, 2020·Acta Paediatrica·Elliot LongFranz E Babl
Mar 18, 2021·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Rujipat SamransamruajkitUNKNOWN Pediatric Sepsis Asian Collaboration (PEDSAC) Investigators and on behalf of the Pediatric Acute and Critical Care Medicine
Aug 27, 2021·Archives of Disease in Childhood. Education and Practice Edition·Deirdre Philbin, Dani Hall

❮ Previous
Next ❯

Software Mentioned

R Foundation for Statistical Computing
Research Electronic Data Platform ( REDCap )
R
Quality in Prognosis Studies
Insight Scope

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved