Pediatric severe pseudomembranous enteritis treated with fecal microbiota transplantation in a 13-month-old infant

Biomedical Reports
Jiayi WangTing Zhang

Abstract

Fecal microbiota transplantation (FMT) is a procedure used to restore the intestinal microbiota of a diseased individual using indigenous intestinal microorganisms from a healthy donor. The current case report presents the first case of a 13-month-old male with severe pseudomembranous enteritis (PME) treated with FMT. The infant was admitted to Shanghai Children's Hospital with a 2-month history of diarrhea, and a 1.5-month history of retractable edema, hypoalbuminemia, electrolyte disturbance and malnutrition. Besides necessary nutritional support, the patient was treated twice with oral metronidazole combined with or without vancomycin. Diarrhea was partially remitted. However, the infant had bloody or dark-green feces, and a distended abdomen. On day 96 from the initiation of the disease, a single FMT via a nasal jejuna feeding tube was performed. From day 2 until 4 months post-FMT, the patient presented with no diarrhea, normal feces and a satisfactory weight. To the best of our knowledge, this is the first pediatric PME treated with FMT. The current data show that FMT is an efficient choice for recurrent clostridium difficile infection and PME in adults and a few pediatric cases. Due to a lack of safety and effectiveness d...Continue Reading

References

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Citations

Mar 17, 2016·Pediatric Research·Suchitra K Hourigan, Maria Oliva-Hemker
Feb 9, 2016·Future Microbiology·Nadim CassirBernard La Scola
Feb 24, 2017·Journal of Pediatric Gastroenterology and Nutrition·Jiayi WangGuangjun Yu
Jan 2, 2019·Tropical Medicine and Infectious Disease·Deirdre A Collins, Thomas V Riley
Jan 7, 2017·World Journal of Gastroenterology : WJG·Alice Yuxin WangNikhil Pai
Jun 4, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Monica GulatiLipika Chandwani

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