Pediatric-to-adult Transition and Medication Adherence in Patients with Inflammatory Bowel Disease

Inflammatory Bowel Diseases
Jayson JeganathanRupert W Leong

Abstract

Medication nonadherence is common in inflammatory bowel disease and is associated with poor outcomes. There has been no study on pediatric-to-adult transition as a risk factor for nonadherence in inflammatory bowel disease, which has been demonstrated in other diseases. We aimed to assess whether transitioned (TR) patients have higher nonadherence rates than young adults (YAs) diagnosed in adulthood. Consecutive ambulatory subjects were prospectively recruited and completed the validated Medication Adherence Reporting Scale (MARS), with the primary outcome being adherence differences between group age-matched TR and YA groups. Pediatric subjects were taken as the control group. Perceptions of medication-related necessity and concerns were assessed with the Beliefs about Medicines Questionnaire (BMQ). Nonadherers (defined as MARS ≤16) received the Inflammatory Bowel Diseases Pharmacist Adherence Counselling (IPAC) intervention and adherence change was reassessed after 6 months as a secondary outcome. Adherence in TR patients (n = 38, mean age 20.4, 13.2% nonadherent) was noninferior to and numerically better than YAs diagnosed in adulthood (n = 41, mean age 21.2, 24.4%). Nonadherence in the pediatric control group (n = 50, mean ...Continue Reading

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Citations

Apr 16, 2019·The American Journal of Gastroenterology·Tara Menon, Anita Afzali
Mar 21, 2020·Inflammatory Bowel Diseases·James K StoneCharles N Bernstein
Jan 24, 2019·Pediatric Gastroenterology, Hepatology & Nutrition·Jeongseok Kim, Byong Duk Ye
Jan 29, 2021·Expert Opinion on Biological Therapy·Francesco MenzellaAndrea Matucci
Apr 3, 2020·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Olga Maria NardoneFabiana Castiglione

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