Pediatric Wells syndrome (eosinophilic cellulitis) after vaccination: A case report and review of the literature

Pediatric Dermatology
Ashley M YuSandra M Skotnicki

Abstract

A 4-year-old boy presented with erythematous vesicular plaques, ulceration, edema, and pruritus on the left foot and ankle 10 days after receiving the tetanus, diphtheria, pertussis, and polio; measles, mumps, rubella, and varicella; and hepatitis A/B vaccines. Biopsy showed eosinophilic infiltrates and flame figures, suggesting Wells syndrome. Patch testing showed a 1+ reaction to neomycin and aluminum hydroxide, with a recall reaction of Wells syndrome of the feet bilaterally. We report a rare case of pediatric Wells syndrome triggered by nonthimerosal vaccine components confirmed by patch testing.

References

Jul 19, 2003·The Australasian Journal of Dermatology·Karen J KohGeoffrey N Thompson
Apr 25, 2006·Journal of the American Academy of Dermatology·Jacob CalvertRobert Sidbury
Apr 22, 2015·Pediatric Dermatology·Jacqueline K SimpsonNerys Roberts

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Citations

Aug 26, 2020·Expert Review of Clinical Immunology·Lucrezia SartiJean-Christoph Caubet
May 13, 2020·American Journal of Clinical Dermatology·Angelo Valerio Marzano, Giovanni Genovese
Jul 9, 2021·European Journal of Hospital Pharmacy. Science and Practice·Sevil Savaş Erdoğan, Filiz Cebeci Kahraman
Sep 22, 2021·Journal of the European Academy of Dermatology and Venereology : JEADV·L de MontjoyeM Baeck
Jan 12, 2022·Journal of the European Academy of Dermatology and Venereology : JEADV·Yulhee Kim, You Chan Kim

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