Pediculicidal treatment using ethanol and Melia azedarach L

Parasitology Research
João Ricardo RutkauskisTereza Cristina Marino Jorge

Abstract

Pediculosis is an infestation of the scalp caused by Pediculus humanus capitis, known as lice, which affects thousands of people throughout the world. Disease control is achieved by topical insecticides, whose indiscriminate use has led to the emergence of resistant populations of lice. Melia azedarach L. (Meliaceae) is an Asian tree that is found in Brazil, where it is popularly known as cinnamon or santa-bárbara. This study aimed to evaluate a pediculicidal treatment, made from a hydroethanolic extract of M. azedarach, and to study the effect of extraction solvents (ethanol and water) on insect mortality. The chemical composition of crude extract was studied by gas chromatography, identifying 32 methyl esters of fatty acids, with esters of heneicosanoic, palmitic, and arachidic acids present in greatest abundance. The (1)H and (13)C nuclear magnetic resonance (NMR) spectra suggested the presence of flavonoids and terpenes. Quercetin-3-O-β-D-glucopyranoside (1) and quercetin-3-O-β-D-glucopyranosyl-(1 → 6)-O-β-D-glucopyranoside (2) were isolated from the extract. The bioassay of pediculicidal activity shows that the M. azedarach extract had a pediculicidal activity, inducing the death of all lice faster than 1% permethrin, a to...Continue Reading

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Citations

Oct 16, 2015·Parasitology Research·María Mercedes GutiérrezAdriana Alicia Ferrero
Aug 17, 2016·BioMed Research International·Abdoul Karim SangaréDidier Raoult
Aug 3, 2016·Parasitology Research·Fathy Abdel-GhaffarNorman-Philipp Hoff
Mar 10, 2018·Parasite : Journal De La Société Française De Parasitologie·Kerdalidec CandyArezki Izri
Mar 9, 2021·Chemistry & Biodiversity·Shyam Sharan ShresthaSangeeta Rajbhandary

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