Pedigree-based Analysis of Inherited and Noninherited Risk Factors of Congenital Heart Defects

Early Human Development
Yuan YuanGuoying Huang

Abstract

Although congenital heart defect (CHD) pedigrees are rare, they are generally taken as evidence of the existence of a genetic etiologic mechanism or environmental factors common to family members, or a combination of both. Therefore, the analysis of CHD pedigrees is important for bridging the gap in our knowledge of its etiology. To assess the prevalence of CHD and evaluate the nongenetic factors in the CHD patients and healthy controls in the pedigrees. Observational retrospective study. Twenty-three CHD pedigrees were involved in the prevalence statistics; thirty-nine CHD cases and fifty-two healthy controls in the CHD pedigrees were included in the family-based noninherited factors analysis. The three-degree relatives and overall CHD prevalence were calculated. Thirty-four noninherited risk factors were compared between the CHD and control groups, first by univariate analysis and later by multivariable logistic stepwise regression analysis. The CHD prevalence of the probands' relatives in all pedigrees was 8.0%, and it was 10.9%, 2.9% and 11.9% in first-, second- and third-degree relatives, respectively. The three risk factors, including maternal febrile illnesses (OR=14.2, 95%CI: [1.5 - 133.7]), influenza (OR=6.9 [2.0 - 23....Continue Reading

References

Mar 15, 1983·The American Journal of Cardiology·P CoroneD Berthet-Bondet
Mar 29, 2002·Archives of Disease in Childhood·S DastgiriW H Gilmour
Jun 27, 2002·Journal of the American College of Cardiology·Julien I E Hoffman, Samuel Kaplan
Aug 31, 2007·Birth Defects Research. Part A, Clinical and Molecular Teratology·Lorenzo D BottoUNKNOWN National Birth Defects Prevention Study
Oct 10, 2007·Circulation·François Cambien, Laurence Tiret
Dec 7, 2007·Journal of Medical Genetics·A Tomita-MitchellE Goldmuntz
Mar 3, 2009·American Heart Journal·Nina OyenMads Melbye
Jul 15, 2009·Circulation·Nina ØyenMads Melbye
Feb 23, 2010·Circulation. Cardiovascular Genetics·Nina OyenMads Melbye
Sep 25, 2010·Journal of the American College of Cardiology·Paul KhairyAriane J Marelli
Nov 4, 2010·Nature Reviews. Cardiology·Teun van der BomBarbara J M Mulder
Oct 18, 2011·Early Human Development·N Margreth van der LugtFrans J Walther
Feb 18, 2012·Circulation. Cardiovascular Genetics·Cammon B ArringtonNeil E Bowles
Aug 7, 2012·The Medical Journal of Australia·Gillian M BlueDavid S Winlaw
Feb 16, 2013·Circulation Research·Akl C FahedChristine E Seidman
Apr 30, 2013·Environmental Research·Keren Agay-ShayChava Peretz
Jul 10, 2013·Future Cardiology·Cammon B ArringtonNeil E Bowles
Dec 25, 2013·Human Reproduction·J M LuteijnH Dolk
Jan 11, 2014·Environmental Research·Emilio Antonio Luca GianicoloGiuseppe Latini
Jan 28, 2014·The Canadian Journal of Cardiology·Steven C GreenwayBrenda Gerull
May 6, 2014·European Journal of Medical Genetics·Seema R Lalani, John W Belmont
May 9, 2014·Journal of Perinatology : Official Journal of the California Perinatal Association·Q Y ShiY L Zhang

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