Pedigree selection and information content

Current Protocols in Human Genetics
E R Hauser, D E Weeks

Abstract

This unit covers the important criteria and methods for appropriately selecting pedigrees for linkage analysis. It includes methods for determining the power of a dataset to detect genetic loci for both model-based (lod score) and model-free (affected sib-pair, affected-relative pair) analyses. This unit covers the important criteria and methods for appropriately selecting pedigrees for linkage analysis.

References

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