PEDOT:PSS interfaces stabilised using a PEGylated crosslinker yield improved conductivity and biocompatibility

Journal of Materials Chemistry. B, Materials for Biology and Medicine
Matteo SolazzoMichael G Monaghan

Abstract

The rapidly expanding fields of bioelectronics, and biological interfaces with electronic sensors and stimulators, are placing an increasing demand on candidate materials to serve as robust surfaces that are both biocompatible, stable and electroconductive. Amongst conductive polymers, poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) is a promising material in biomedical research due to its appropriate stability and high conductivity, however its intrinsic solubility requires a crosslinking process that can limit its conductivity and biocompatibility. Poly(ethylene glycol) is known to be a suitably anti-immunogenic moiety and its derivatives have been widely used for biomedical applications. In this study we investigate the application of poly(ethylene glycol)diglycidyl ether (PEGDE) as an effective crosslinker and conductive filler for PEDOT:PSS. From our interpretation of XPS analysis we hypothesise that the crosslinking reaction is occurring via the epoxy ring of PEGDE interacting with the sulfonic groups of excel PSS chains, which reaches a saturation at 3 w/v% PEGDE concentration. PEGDE crosslinked films did not disperse in aqueous environments, had enhanced electrical conductivity and imparted a signifi...Continue Reading

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Citations

Nov 19, 2020·Advanced Healthcare Materials·Byron Llerena ZambranoJaehong Lee
Mar 9, 2021·Frontiers in Bioengineering and Biotechnology·Laura SordiniJorge Morgado
Sep 29, 2020·Advanced Drug Delivery Reviews·Dinorath Olvera, Michael G Monaghan
Jul 3, 2021·Polymers·Małgorzata SkorupaKatarzyna Krukiewicz
Jul 6, 2021·Biomaterials Science·Fábio F F GarrudoFrederico Castelo Ferreira
Aug 29, 2021·Polymers·Laura SordiniFrederico Castelo Ferreira

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Methods Mentioned

BETA
biosensors
X-ray

Software Mentioned

ImageJ
PerkinElmer® Spectrum
CasaXPS
GraphPad
EIS Spectrum Analyzer
GraphPad Prism

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