PEDOT:PSS Interfaces Support the Development of Neuronal Synaptic Networks with Reduced Neuroglia Response In vitro

Frontiers in Neuroscience
Giada CellotLaura Ballerini

Abstract

The design of electrodes based on conductive polymers in brain-machine interface technology offers the opportunity to exploit variably manufactured materials to reduce gliosis, indeed the most common brain response to chronically implanted neural electrodes. In fact, the use of conductive polymers, finely tailored in their physical-chemical properties, might result in electrodes with improved adaptability to the brain tissue and increased charge-transfer efficiency. Here we interfaced poly(3,4-ethylenedioxythiophene):poly(styrene sulfonate) ( PSS) doped with different amounts of ethylene glycol (EG) with rat hippocampal primary cultures grown for 3 weeks on these synthetic substrates. We used immunofluorescence and scanning electron microscopy (SEM) combined to single cell electrophysiology to assess the biocompatibility of PSS in terms of neuronal growth and synapse formation. We investigated neuronal morphology, density and electrical activity. We reported the novel observation that opposite to neurons, glial cell density was progressively reduced, hinting at the ability of this material to down regulate glial reaction. Thus, PSS is an attractive candidate for the design of new implantable electrodes, controlling the extent o...Continue Reading

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Citations

Aug 6, 2019·Frontiers in Systems Neuroscience·Kristina E Kitko, Qi Zhang
Sep 25, 2019·Materials Science & Engineering. C, Materials for Biological Applications·Nela MarákováMarián Lehocký
Mar 2, 2021·Frontiers in Bioengineering and Biotechnology·Laura M FerrariJaume Del Valle
Mar 7, 2021·Polymers·I Jénnifer GómezNuria Alegret
Sep 3, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Mahima BansalDarren Svirskis
Mar 23, 2021·Cerebral Cortex·Angelique C PaulkSydney S Cash
Oct 5, 2018·ACS Applied Materials & Interfaces·Tian-Yu WangDavid Wei Zhang
Nov 27, 2018·ACS Applied Materials & Interfaces·Nuria AlegretMaurizio Prato
Aug 28, 2021·International Journal of Molecular Sciences·Alice AbendMareike Zink

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Methods Mentioned

BETA
scanning electron microscopy
AFM

Software Mentioned

Gwyddion
pClamp
LabView
Origin
NeuroGrid
Fiji

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