Pedunculopontine nucleus deep brain stimulation changes spinal cord excitability in Parkinson's disease patients

Journal of Neural Transmission
Mariangela PierantozziAlessandro Stefani

Abstract

Bilateral peduncolopontine nucleus (PPN) and subthalamic nucleus (STN) deep brain stimulation (DBS) was performed in six-advanced Parkinson's disease (PD) patients. We report the effect of both PPN-DBS (25 Hz) and STN-DBS (185 Hz) on patient spinal reflex excitability by utilizing the soleus-Hoffman reflex (HR) threshold. Compared to controls (n = 9), patients showed an increase of HR-threshold, which was scarcely affected by levodopa, but significantly reduced by DBS. In particular, we found that PPN-DBS alone, or plus STN-DBS induced a complete recovery of HR-threshold up to control values. The HR-threshold changes, although do not allow to investigate the contribution of specific intraspinal pathways, suggest that PPN may play a key-role in modulating spinal excitability in PD possibly by improving the basal ganglia-brainstem descending system activity.

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Citations

Jun 10, 2011·Experimental Brain Research·João CostaJosep Valls-Solé
Feb 15, 2011·Journal of Neural Transmission·Paolo MazzoneEugenio Scarnati
Apr 13, 2011·Journal of Neural Transmission·Ludvic ZrinzoJanice L Holton
Apr 12, 2011·Journal of Neural Transmission·P ProficeV Di Lazzaro
Apr 9, 2008·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Matthew D JohnsonJerrold L Vitek
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Aug 22, 2021·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Angelo InsolaEugenio Scarnati

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