Peer influences on drug self-administration: social facilitation and social inhibition of cocaine intake in male rats.

Psychopharmacology
Mark A Smith

Abstract

One problem facing animal models of intravenous drug self-administration, particularly those examining social manipulations, is that subjects must be removed from the home environment and separated from cagemates during testing. This represents a limitation of animal models because it fails to capture the complex social environments in which drug use often occur. The aim of this study was to examine intravenous cocaine self-administration in isolated and socially housed rats, with the caveat that the socially housed subjects lived together 24 h/day, including during daily self-administration sessions. As a secondary aim, the study examined the impact of a companion that also self-administered cocaine versus a companion without access to cocaine. Male rats were obtained at weaning and reared in isolated or pair-housed conditions for 6 weeks. Rats were then implanted with intravenous catheters and transferred to custom-built operant conditioning chambers that served as home cages for the remainder of the study. For some socially housed subjects, both rats had simultaneous access to cocaine; for others, only one rat of the pair had access to cocaine. Cocaine self-administration was facilitated in socially housed rats if both membe...Continue Reading

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Citations

Aug 17, 2012·Psychopharmacology·Michael A NaderDrake Morgan
Feb 16, 2013·Behavioural Pharmacology·Geoffrey W PeitzMark A Smith
Feb 21, 2014·Psychopharmacology·Viviana TrezzaLouk J M J Vanderschuren
Jun 1, 2014·Drug and Alcohol Dependence·Mark A SmithJustin C Strickland
May 29, 2013·Psychopharmacology·Matthew G Kirkpatrick, Harriet de Wit
Mar 5, 2016·Addiction Biology·Jill B BeckerBeth Glover Reed
Jul 15, 2015·Pharmacology, Biochemistry, and Behavior·Justin C Strickland, Mark A Smith
Jan 1, 2014·Drug and Alcohol Dependence·Mark A Smith, Elizabeth G Pitts
Aug 12, 2014·Journal of Neuroscience Methods·Ryan T LacyMark A Smith
Nov 25, 2016·Frontiers in Behavioral Neuroscience·Mark A SmithAndrea M Robinson
Oct 20, 2018·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Lindsey B KuiperLique M Coolen
Oct 7, 2018·Psychopharmacology·Virginia G WeissMichael T Bardo
Mar 24, 2020·Nature Protocols·Marco Venniro, Yavin Shaham
Oct 17, 2018·Nature Neuroscience·Marco VenniroYavin Shaham
Jan 20, 2021·Drug and Alcohol Dependence·Samuel F AcuffJustin C Strickland
Feb 27, 2019·Neuropharmacology·Yann PellouxChristelle Baunez
May 3, 2021·Behavioural Brain Research·Karl T SchmidtMark A Smith
Aug 18, 2021·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Marco VenniroYavin Shaham

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