PEG-conjugated pyrrole-based polymers: one-pot multicomponent synthesis and self-assembly into soft nanoparticles for drug delivery

Chemical Communications : Chem Comm
Alexandre MoquinAshok Kakkar

Abstract

Polyethylene glycol grafted pyrrole-based conjugated polymers are synthesized through a one-pot multicomponent methodology, the self-assemblies of which enable nanoparticle size-selective encapsulation of drug molecules and their sustained release. Efficient loading of curcumin through drug-nanoparticle core interactions is probed using FRET, and the inherently fluorescent nature of polypyrrole could be used to detect these nanocarriers intracellularly.

References

Dec 20, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Reecha WadhwaXinyan Tracy Cui
Feb 20, 2007·Toxicology and Applied Pharmacology·Mohammad AtharArianna L Kim
Jul 11, 2009·The AAPS Journal·Jayaraj RavindranBharat B Aggarwal
Mar 17, 2010·Biochemical and Biophysical Research Communications·Antero SalminenKai Kaarniranta
May 2, 2015·Nanoscale·Devleena SamantaRichard N Zare
Dec 27, 2015·Nutrition·Gustavo Tomas Diaz-GereviniAldo Renato Eynard
Jan 8, 2016·Journal of the American Chemical Society·Mark W TibbittRobert Langer
Jul 30, 2016·Journal of the American Chemical Society·Laure V KayserBruce A Arndtsen
Jul 7, 2017·Clinical Science·Ajaikumar B KunnumakkaraBharat B Aggarwal
Apr 24, 2018·Biomacromolecules·Baolin Guo, Peter X Ma

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Citations

Apr 25, 2020·Biotechnology Journal·Johannes W M Osterrieth, David Fairen-Jimenez
Aug 19, 2020·Macromolecular Rapid Communications·Xiaolin LiuBen Zhong Tang
Oct 8, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Brenda G MolinaCarlos Aleman
Dec 17, 2020·Macromolecular Rapid Communications·Ki-Young Yoon, Guangbin Dong
Sep 9, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Haonan LiKui Luo
Jul 25, 2021·Nanomedicine : Nanotechnology, Biology, and Medicine·Evan Rizzel GranDusica Maysinger

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Methods Mentioned

BETA
biosensors
NMR
dynamic light scattering
fluorescence resonance
FRET

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