PEG-Derivatized Dual-Functional Nanomicelles for Improved Cancer Therapy

Frontiers in Pharmacology
Yanping LiJinhan He

Abstract

Polymeric micelles have attracted considerable attention for effective delivery of poorly water-soluble cancer drugs. Polyethylene glycol (PEG), which has been approved for human use by the US Food and Drug Administration, is the most commonly used hydrophilic component of polymeric micelles because it is biocompatible and biodegradable. One disadvantage of traditional polymeric micelles is that they include a large amount of inert carrier materials, which do not contribute to therapeutic activity but increase cost and toxicity risk. A better alternative may be "dual-functional" micellar carriers, in which the hydrophobic carrier material (conjugated to PEG) has intrinsic therapeutic activity that complements, or even synergizes with, the antitumor activity of the drug cargo. This review summarizes recent progress in the development of PEG-derivatized dual-functional nanomicelles and surveys the evidence of their feasibility and promise for cancer therapy.

References

Aug 18, 2000·The Journal of Surgical Research·M P Malafa, L T Neitzel
Sep 28, 2000·Molecular Medicine Today·Y Kloog, A D Cox
Jan 29, 2002·Surgery·Mokenge P MalafaMichele King
Feb 21, 2002·Biochimica Et Biophysica Acta·Julie JodoinRichard Beliveau
Mar 7, 2002·International Journal of Pharmaceutics·Anil K SinglaDeepika Aggarwal
Aug 14, 2002·Cancer Treatment Reviews·G Molineux
Oct 3, 2002·Nature Reviews. Cancer·Theresa M Allen
Jul 5, 2003·Lancet·Joseph F Pizzolato, Leonard B Saltz
Mar 12, 2004·Expert Opinion on Investigational Drugs·Franco Zunino, Graziella Pratesi
Apr 7, 2004·Advanced Drug Delivery Reviews·Karel Ulbrich, Vladimír Subr
Apr 15, 2004·Journal of Controlled Release : Official Journal of the Controlled Release Society·Hyuk Sang Yoo, Tae Gwan Park
May 26, 2004·International Journal of Pharmaceutics·K HosteE Schacht
Jun 16, 2004·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yong Woo ChoKinam Park
Oct 16, 2004·The Journal of Pharmacy and Pharmacology·Yuying MeiJianwen Liu
Nov 17, 2004·Journal of Controlled Release : Official Journal of the Controlled Release Society·Hyuk Sang Yoo, Tae Gwan Park
Dec 1, 2004·The Journal of Nutrition·Kimberly KlineBob G Sanders
Dec 14, 2004·Journal of Controlled Release : Official Journal of the Controlled Release Society·Kang Moo HuhKinam Park
Jan 5, 2005·Nature Reviews. Cancer·Bruce A Chabner, Thomas G Roberts
Aug 6, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Hee-Jeong YoukSoo-Jeong Lim
Jan 20, 2006·Pharmaceutical Research·Panayiotis P ConstantinidesStanley S Davis
Feb 13, 2007·Nanomedicine : Nanotechnology, Biology, and Medicine·Otilia M KooHayat Onyuksel
Jun 16, 2007·Frontiers in Bioscience : a Journal and Virtual Library·Sharmila ShankarRakesh K Srivastava
Jul 24, 2007·Immunology Letters·Maria ZamanakouVaios Karanikas
Nov 6, 2007·Frontiers in Bioscience : a Journal and Virtual Library·Francesca Greco, Maria J Vicent
Dec 7, 2007·Cancer Detection and Prevention·Fulvia FarabegoliRoberta Piva
Dec 8, 2007·Journal of Pharmaceutical Sciences·Jubo LiuChristine Allen
Dec 18, 2007·International Journal of Pharmaceutics·Tatsuhiro Ishida, Hiroshi Kiwada
Apr 17, 2008·Cancer Research·Srinivas Nagaraj, Dmitry I Gabrilovich
Dec 17, 2008·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·H MaedaJ Daruwalla
May 9, 2009·Advanced Drug Delivery Reviews·Younsoo Bae, Kazunori Kataoka
Feb 18, 2010·Proceedings of the National Academy of Sciences of the United States of America·Michael A CurranJames P Allison
Jun 15, 2010·Nanomedicine : Nanotechnology, Biology, and Medicine·Uttam KedarVilasrao Kadam

❮ Previous
Next ❯

Citations

Apr 29, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Cristian ValenzuelaJianhua Zhang
Mar 19, 2020·Molecular Pharmaceutics·Pan LiDing-Kun Zhang

❮ Previous
Next ❯

Methods Mentioned

BETA
xenograft

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.