Peg-interferon plus nucleotide analogue treatment versus no treatment in patients with chronic hepatitis B with a low viral load: a randomised controlled, open-label trial

The Lancet. Gastroenterology & Hepatology
Annikki de NietHendrik W Reesink

Abstract

Antiviral treatment is currently not recommended for patients with chronic hepatitis B with a low viral load. However, they might benefit from acquiring a functional cure (hepatitis B surface antigen [HBsAg] loss with or without formation of antibodies against hepatitis B surface antigen [anti-HBs]). We assessed HBsAg loss during peg-interferon-alfa-2a (peg-IFN) and nucleotide analogue combination therapy in patients with chronic hepatitis B with a low viral load. In this randomised controlled, open-label trial, patients were enrolled from the Academic Medical Center (AMC), Amsterdam, Netherlands. Eligible patients were HBsAg positive and hepatitis B e antigen (HBeAg) negative for more than 6 months, could be treatment naive or treatment experienced, and had alanine aminotransferase (ALT) concentrations less than 5 × upper limit of normal (ULN). Participants were randomly assigned (1:1:1) by a computerised randomisation programme (ALEA Randomisation Service) to receive peg-IFN 180 μg/week plus adefovir 10 mg/day, peg-IFN 180 μg/week plus tenofovir disoproxil fumarate 245 mg/day, or no treatment for 48 weeks. The primary endpoint was the proportion of patients with serum HBsAg loss among those who received at least one dose of s...Continue Reading

Citations

Nov 26, 2019·The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi·Dong Hyun Sinn
Jun 13, 2019·Clinical and Molecular Hepatology·UNKNOWN Korean Association for the Study of the Liver (KASL)
Sep 19, 2020·Journal of Comparative Effectiveness Research·Urbano SbarigiaMaarten Postma
Mar 13, 2019·Expert Opinion on Pharmacotherapy·Hans L Tillmann, Gbeminiyi Samuel
Apr 25, 2019·The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi·Ji Hoon Kim
May 18, 2018·Emerging Microbes & Infections·Xuan-Yi Wang, Yu-Mei Wen
May 21, 2020·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Wen-Juei Jeng, Anna S Lok
Dec 12, 2021·Hepatology Communications·Hannah S J ChoiNorah A Terrault

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