PEG-lipid-PLGA hybrid nanoparticles loaded with berberine-phospholipid complex to facilitate the oral delivery efficiency.

Drug Delivery
Fei YuXiao Dong Chen

Abstract

The natural product berberine (BBR), present in various plants, arouses great interests because of its numerous pharmacological effects. However, the further development and application of BBR had been hampered by its poor oral bioavailability. In this work, we report on polymer-lipid hybrid nanoparticles (PEG-lipid-PLGA NPs) loaded with BBR phospholipid complex using a solvent evaporation method for enhancing the oral BBR efficiency. The advantage of this new drug delivery system is that the BBR-soybean phosphatidylcholine complex (BBR-SPC) could be used to enhance the liposolubility of BBR and improve the affinity with the biodegradable polymer to increase the drug-loading capacity and controlled/sustained release. The entrapment efficiency of the PEG-lipid-PLGA NPs/BBR-SPC was observed to approach approximately 89% which is more than 2.4 times compared with that of the PEG-lipid-PLGA NPs/BBR. To the best of our knowledge, this is the first report on using polymer material for effective encapsulation of BBR to improve its oral bioavailability. The prepared BBR delivery systems demonstrated a uniform spherical shape, a well-dispersed core-shell structure and a small particle size (149.6 ± 5.1 nm). The crystallographic and ther...Continue Reading

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Citations

Sep 14, 2017·Chemical Society Reviews·Handan AcarMatthew V Tirrell
Oct 5, 2017·Drug Delivery·Jun-Zi WuLi-Min Zhu
Jun 1, 2018·Drug Development and Industrial Pharmacy·Hongxue ShenJianming Ju
Mar 15, 2019·Drug Delivery and Translational Research·Salma A SoudiLabiba K El-Khordagui
Apr 21, 2020·Daru : Journal of Faculty of Pharmacy, Tehran University of Medical Sciences·Reza GhaffarzadeganShamsali Rezazadeh
Mar 27, 2020·International Journal of Molecular Sciences·Saikat DewanjeeVincenzo De Feo
Jun 25, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Zhe MaZhidong Liu
Jun 17, 2020·Colloids and Surfaces. B, Biointerfaces·Hossein MajidzadehMichael R Hamblin
May 25, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Elaheh MirhadiBizhan Malaekeh-Nikouei
Dec 11, 2019·European Journal of Medicinal Chemistry·Hamed MortazaviAmir Abbas Momtazi-Borojeni
Dec 27, 2017·Advanced Drug Delivery Reviews·Xuanyu Li, Xingyu Jiang
Aug 4, 2021·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Oi Jin TanUsha Sundralingam
Sep 3, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Yunfeng HanXianrong Lai
Nov 11, 2021·Journal of the American College of Nutrition·Jasleen BhasinVikas Chopra

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