PEG-Phospholipids Coated Quantum Rods as Amplifiers of the Photosensitization Process by FRET

ACS Applied Materials & Interfaces
Reut TimorBenjamin Ehrenberg

Abstract

Singlet oxygen ((1)O2) generated upon photostimulation of photosensitizer molecules is a highly reactive specie which is utilized in photodynamic therapy. Recent studies have shown that semiconductor nanoparticles can be used as donors in fluorescence resonance energy transfer (FRET) process to excite attached photosensitizer molecules. In these studies, their unique properties, such as low nanoscale size, long-term photostability, wide broad absorbance band, large absorption cross section, and narrow and tunable emission bands were used to provide advantages over the traditional methods to produce singlet oxygen. Previous studies that achieved this goal, however, showed some limitations, such as low FRET efficiency, poor colloidal stability, nonspecific interactions, and/or complex preparation procedure. In this work, we developed and characterized a novel system of semiconductor quantum rods (QRs) and the photosensitizer meso-tetra(hydroxyphenyl) chlorin (mTHPC), as a model system that produces singlet oxygen without these limitations. A simple two-step preparation method is shown; Hydrophobic CdSe/CdS QRs are solubilized in aqueous solutions by encapsulation with lecithin and PEGylated phospholipid (PEG-PL) of two lipid leng...Continue Reading

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Citations

Feb 14, 2018·Photochemistry and Photobiology·Niluksha WalalawelaAlexander Greer
Mar 13, 2018·Advanced Healthcare Materials·Dan YangPiaoping Yang
Jan 4, 2018·ACS Applied Materials & Interfaces·Elina HaimovOrit Shefi
Dec 4, 2019·The Journal of Physical Chemistry Letters·Seryio SarisRaffaella Buonsanti
May 17, 2018·Molecular Pharmaceutics·Yan ZhaoXin Ming
Nov 23, 2019·ACS Applied Materials & Interfaces·Elina Haimov-TalmoudOrit Shefi
Dec 8, 2021·Chemical Communications : Chem Comm·Nuria Lafuente-GómezÁlvaro Somoza

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