Peginterferon Therapy in Children With Chronic Hepatitis C: A Nationwide, Multicenter Study in Japan, 2004-2013

Journal of Pediatric Gastroenterology and Nutrition
Mitsuyoshi SuzukiStephen Brooks

Abstract

The aim of the present study was to review the medical treatment of Japanese children and adolescents with chronic hepatitis C in the past 10 years. This nationwide, multicenter study evaluated patients who were younger than 18 years of age when diagnosed with chronic hepatitis C virus (HCV) infection and were treated with pegylated interferon (PEG-IFN) monotherapy or PEG-IFN/ribavirin (RBV) combination therapy between 2004 and 2013. The subjects' median age was 10 (3-18) years, with a male to female ratio of 52:50 and a genotype-1 to genotype-2 ratio of 45:57. Among the 102 patients, 18 received PEG-IFN monotherapy and 84 received PEG-IFN/RBV combination therapy. The IL28B genotype polymorphism was analyzed in patients infected with genotype-1. In patients with HCV genotype-1 infections, sustained virological response (SVR) rates obtained by PEG-IFN monotherapy and by PEG-IFN/RBV combination therapy were 100% (2/2) and 72% (31/43), respectively. In patients with HCV genotype-2 infections, SVRs were 75% (12/16) and 100% (41/41), respectively. In 32 genotype-1 patients available for the IL28B genotype (rs8099917), SVR was achieved in more patients in the IL28B major allele group than in the minor allele group (15/17 vs 7/15, P =...Continue Reading

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Citations

Jan 20, 2017·Pediatrics International : Official Journal of the Japan Pediatric Society·Mitsuyoshi SuzukiYoko Miyoshi
Feb 7, 2018·Hepatology Communications·James E Squires, William F Balistreri
Jul 7, 2017·Journal of Translational Internal Medicine·Abd ElrazekTamer Z Salem
May 25, 2020·The Journal of Pediatrics·James E Squires, William F Balistreri

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Methods Mentioned

BETA
genotyping
biopsies

Software Mentioned

SPSS Statistics

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