Pegylated interferon alfa-2b plus ribavirin in the retreatment of interferon-ribavirin nonresponder patients

Gastroenterology
Gloria TalianiNonresponder Retreatment Group

Abstract

Inadequate data are available about retreatment of nonresponders to interferon (IFN) and ribavirin. Thus, this study evaluated the efficacy and tolerability of a 48-week therapy with pegylated IFN-alpha-2b plus high-dose ribavirin in patients who have failed to respond to the combination. Treatment up to 48 weeks also in patients who have failed to clear hepatitis C virus (HCV) RNA by week 24 was also evaluated. One hundred forty-one patients who previously did not respond to IFN and ribavirin, 86% with genotype 1 or 4 infection, 52% with high viral load (>800.000 IU/mL), 22% with cirrhosis, were retreated with pegylated IFN-alpha-2b 1.5 microg/kg per week and ribavirin 1000-1200 mg/day for 48 weeks and followed up for 24 weeks. By intent-to-treat analysis, 20% of patients achieved a sustained virologic response (SVR). SVR of genotype 1 patients was 19%. Independent predictors of SVR were low gamma-glutamyltransferase levels (OR, 22.9; 95% CI: 6.6-79.6) and low viral load (OR, 3.8; 95% CI: 1.1-12.6). Twelve (23%) out of 51 patients who were HCV RNA positive after 24 weeks of therapy achieved a late virologic response (after week 24) and 5 (10%) of them, all with genotype 1, achieved an SVR. Genotype was not associated with resp...Continue Reading

Citations

Sep 10, 2008·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Gaetano ScottoGioacchino Angarano
Jan 28, 2010·Journal of Clinical Biochemistry and Nutrition·Naruaki KohgeYoshikazu Kinoshita
Oct 4, 2012·Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association·Abdullah S AlghamdiUNKNOWN Saudi Association for the Study of Liver Diseases and Transplantation
Aug 27, 2009·Biologics : Targets & Therapy·Stevan A Gonzalez, Emmet B Keeffe
Aug 19, 2007·Liver International : Official Journal of the International Association for the Study of the Liver·Abdurrahman SagirDieter Häussinger
Nov 21, 2007·Journal of Viral Hepatitis·E Jenny Heathcote
Oct 9, 2007·Liver International : Official Journal of the International Association for the Study of the Liver·Jilling F BergmannRobert J de Knegt
Apr 6, 2016·Clinical and Molecular Hepatology·UNKNOWN Korean Association for the Study of the Liver
Oct 13, 2007·Expert Opinion on Pharmacotherapy·Rohit Satoskar, Donald M Jensen
Jul 7, 2007·Archives of Medical Research·Roberto J Firpi, David R Nelson
Nov 26, 2009·Expert Review of Gastroenterology & Hepatology·Catherine FrançoisEric Nguyen-Khac
Mar 31, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Marc G GhanyUNKNOWN American Association for the Study of Liver Diseases
Apr 7, 2007·Current Opinion in Gastroenterology·Jessica Tan, Anna Sf Lok
Apr 18, 2008·Current Gastroenterology Reports·Emmanuel Thomas, Michael W Fried
Jul 19, 2008·Journal of Viral Hepatitis·M Gambarin-Gelwan, I M Jacobson
Jul 25, 2009·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Tatsuki IchikawaKatsumi Eguchi
Feb 12, 2009·Liver International : Official Journal of the International Association for the Study of the Liver·Harald FarnikStefan Zeuzem
Feb 12, 2009·Liver International : Official Journal of the International Association for the Study of the Liver·Jenny Heathcote
Nov 7, 2009·Expert Opinion on Pharmacotherapy·Hidenori Toyoda, Takashi Kumada
Sep 1, 2011·Digestive Diseases and Sciences·Christopher M MooreDavid H Van Thiel
Apr 1, 2012·Hepatology International·Masao OmataGeoffrey W McCaughan
Sep 28, 2013·Gut and Liver·Hyun Chin ChoSeung Woon Paik
Jan 22, 2013·Hepatology Research : the Official Journal of the Japan Society of Hepatology·
Jul 18, 2014·Clinical and Molecular Hepatology·UNKNOWN Korean Association for the Study of the Liver (KASL)
Jun 16, 2010·Journal of Gastroenterology and Hepatology·Ching-Sheng HsuJia-Horng Kao
Dec 24, 2010·Journal of Clinical Pharmacy and Therapeutics·M Trapero-MarugánR Moreno-Otero

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