Pegylated-interferon-associated retinopathy in chronic hepatitis patients

Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde
Ji Won Lim, Min-Cheol Shin

Abstract

To investigate the clinical features of pegylated-interferon (PEG-IFN)-associated retinopathy in chronic hepatitis patients. We examined a consecutive case series of 46 patients who were treated with PEG-IFN for chronic hepatitis C or B between October 2007 and September 2008. All patients underwent regular ophthalmologic examinations every 3 weeks during the 6 months after treatment. Ten of the 46 patients (21.73%) developed retinal abnormalities. PEG-IFN-associated retinopathy occurred a mean of 7.25 +/- 10.28 weeks after treatment and manifested itself as cotton wool spots and retinal hemorrhages. All patients, except for 1 with a retinal vein occlusion, recovered without cessation of treatment. PEG-IFN-associated retinopathy in chronic hepatitis patients was reversible, and patients recovered without visual complications; however, 1 patient did present with an irreversible visual impairment. This type of retinopathy is usually asymptomatic, and clinicians should closely observe patients for 3 months after treatment.

Citations

Mar 10, 2011·Nature Reviews. Gastroenterology & Hepatology·Mark S SulkowskiOlav Dalgard
Dec 24, 2013·World Journal of Gastroenterology : WJG·Roderick O'DayGolo Ahlenstiel
Jul 27, 2010·Optometry : Journal of the American Optometric Association·Shelly Adams, Mark Ostermeier
Sep 9, 2011·Ophthalmic Surgery, Lasers & Imaging : the Official Journal of the International Society for Imaging in the Eye·Elad MoisseievShimon Kurtz
Mar 4, 2014·The Cochrane Database of Systematic Reviews·Goran HauserLise Lotte Gluud
May 29, 2021·Survey of Ophthalmology·Supriya AroraJay Chhablani

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.