PEGylated Lipid bilayer coated mesoporous silica nanoparticles for co-delivery of paclitaxel and curcumin: Design, characterization and its cytotoxic effect

International Journal of Pharmaceutics
Jiahao LinDegui Lin

Abstract

Highly ordered mesoporous silica nanoparticles (MSNs) with pore diameter of 2.754nm and particle size of 115±15nm were prepared with etching method. Homogeneous PEGylated lipid bilayer with 10-15nm thickness was coated around the surface of MSNs using film hydration method. Systematic optimization and characterization of co-encapsulation process of paclitaxel (Tax) and curcumin (Cur) into PEGylated lipid bilayer coated mesoporous silica nanoparticles (PLMSNs) were performed carrying out single factor test, associated with Box-Behnken Design. The concentration of encapsulated drugs was measured by reversed phase high performance liquid chromatography (RP-HPLC) method. Optimal factor settings were as follows: 50mg MSNs, ratio of MSNs to lipid (w/w)=1:1.11, and ratio of lipid to CHO (w/w)=3.93:1. The average experimental EETax, EECur and stability score value were (77.48±2.73) %, (30.70±3.56) % and 4 point respectively based on the conditions mentioned above. Morphology determination of Tax-Cur-PLMSNs revealed that the composite nanoparticles were spherical particals with uniform dispersion. In vitro release experiment indicated that PLMSNs improved dissolution of Tax compared to Tax powder suspension and exhibited sustained relea...Continue Reading

Citations

Feb 27, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Meng XieHaijun Shen
Sep 10, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Raj KumarYogendra Kumar Mishra
Aug 14, 2020·Nanomaterials·Sibusiso Alven, Blessing Atim Aderibigbe
Apr 30, 2020·International Journal of Nanomedicine·Heshu Sulaiman RahmanNoorjahan Banu Alitheen
Aug 21, 2020·Journal of Drug Targeting·Mohsen GhaferiSeyed Ebrahim Alavi
Jan 5, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Bruna G CarvalhoLucimara G de la Torre
Aug 20, 2019·Seminars in Cancer Biology·Dharambir KashyapAnupam Bishayee
Sep 13, 2020·International Journal of Pharmaceutics·Kang XiongShaoZhi Fu
Mar 9, 2021·Frontiers in Veterinary Science·Guillermo ValdiviaLaura Peña
Mar 14, 2020·International Journal of Pharmaceutics·Suzana Gonçalves CarvalhoMarlus Chorilli
Jan 19, 2021·ACS Biomaterials Science & Engineering·Yang XingShaomin Shuang

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