PEGylated multi-walled carbon nanotubes as versatile vector for tumor-specific intracellular triggered release with enhanced anti-cancer efficiency: Optimization of length and PEGylation degree

Colloids and Surfaces. B, Biointerfaces
Xubo ZhaoPeng Liu

Abstract

PEGylated multi-walled carbon nanotubes (PEG-MWCNTs) were optimized as versatile vector for tumor-specific intracellular triggered release of doxorubicin (DOX), based on the effect of their length and PEGylation degree on the cytotoxicity and DOX-loading capacity. The length and surface carboxyl groups of the carboxylated multi-walled carbon nanotubes (CMWCNTs) were easily tailored by adjusting the oxidation time. The longer CMWCNTs or those with high carboxyl group content showed obvious cytotoxicity, while the PEG-MWCNTs ≤ 300 nm showed better cytocompatibility. The PEG-MWCNTs-3 of about 300 nm was selected as drug delivery vector, possessing a high drug-loading capacity of 0.55 mg/mg. They released DOX rapidly under lower pH media mimicking the tumor microenvironment with cumulative release of 57% within 24 h, while the premature leakage under the simulated physiological condition was only 10%. The WST-1 assays demonstrated the DOX-loaded PEG-MWCNTs-3 exhibited the enhanced inhibitory efficiency against HepG2 cells, in comparison with free DOX.

Citations

Nov 13, 2019·Artificial Cells, Nanomedicine, and Biotechnology·Wen LiYuanyan Liu
Sep 11, 2020·Biotechnology and Applied Biochemistry·Maria NicolettiElisa Fasoli
Mar 1, 2019·International Journal of Molecular Sciences·Safia NazJinghua Chen
Aug 23, 2021·Colloids and Surfaces. B, Biointerfaces·Rahul ChadarPrashant Kesharwani

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