PEGylated self-assembled enzyme-responsive nanoparticles for effective targeted therapy against lung tumors

Journal of Nanobiotechnology
Fangyuan GuoGensheng Yang

Abstract

Matrix-metalloproteinases, which are overexpressed in many types of cancer, can be applied to improve the bioavailability of chemotherapeutic drugs and guide therapeutic targeting. Thus, we aimed to develop enzyme-responsive nanoparticles based on a functionalized copolymer (mPEG-Peptide-PCL), which was sensitive to matrix metalloproteinase, as smart drug vesicles for enhanced biological specificity and reduced side effects. The rate of in vitro curcumin (Cur) release from Cur-P-NPs was not markedly accelerated in weakly acidic tumor microenvironment, indicating a stable intracellular concentration and a consistent therapeutic effect. Meanwhile, P-NPs and Cur-P-NPs displayed prominent biocompatibility, biostability, and inhibition efficiency in tumor cells. In addition, Cur-P-NPs showed higher fluorescence intensity than Cur-NPs in tumor cells, implying enhanced cell permeability and targeting ability. Moreover, the internalization and intracellular transport of Cur-P-NPs were mainly via macropinocytosis. Studies of pharmacodynamics and cellular uptake in vitro and biodistribution in vivo demonstrated that Cur-P-NPs had stronger target efficiency and therapeutic effect than Cur-DMSO and Cur-NPs in tumor tissue. Results indicate...Continue Reading

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Citations

Jan 29, 2019·Current Topics in Medicinal Chemistry·Yanan LiFeifei An
May 1, 2019·Proceedings of the National Academy of Sciences of the United States of America·Sara Maslanka FigueroaAchim Goepferich
Apr 8, 2020·Nanoscale Horizons : the Home for Rapid Reports of Exceptional Significance in Nanoscience and Nanotechnolgy·Li KongAlexander Kros
Jul 14, 2019·AAPS PharmSciTech·Karthikeyan Selvaraj, Bong-Kyu Yoo
Oct 3, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Sara Maslanka FigueroaAchim Goepferich

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Methods Mentioned

BETA
oncotherapy
fluorescence microscopy
flow cytometry

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