PEGylated-thymoquinone-nanoparticle mediated retardation of breast cancer cell migration by deregulation of cytoskeletal actin polymerization through miR-34a

Biomaterials
Saurav BhattacharyaArghya Adhikary

Abstract

Thymoquinone (TQ), a major active constituent of black seeds of Nigella sativa, has potential medical applications including spectrum of therapeutic properties against different cancers. However, little is known about their effect on breast cancer cell migration, which is the cause of over 90% of deaths worldwide. Herein, we have synthesized TQ-encapsulated nanoparticles using biodegradable, hydrophilic polymers like polyvinylpyrrolidone (PVP) and polyethyleneglycol (PEG) to overcome TQ's poor aqueous solubility, thermal and light sensitivity as well as consequently, minimal systemic bioavailability which can greatly improve the cancer treatment efficiency. Sizes of synthesized TQ-Nps were found to be below 50 nm and they were mostly spherical in shape with smooth surface texture. Estimation of the zeta potential also revealed that all the three TQ-Nps were negatively charged which also facilitated their cellular uptake. In the present investigation, we provide direct evidence that TQ-Nps showed more efficiency in killing cancer cells as well as proved to be less toxic to normal cells at a significantly lower dose than TQ. Interestingly, evaluation of the anti-migratory effect of the TQ-Nps, revealed that PEG4000-TQ-Nps showed ...Continue Reading

References

Feb 1, 1981·Archives of Biochemistry and Biophysics·J R WrightP R Miles
Feb 1, 1996·Current Opinion in Cell Biology·S H Zigmond
Oct 6, 1997·Genes & Development·L Van Aelst, C D'Souza-Schorey
Apr 27, 2001·Seminars in Cancer Biology·J S CondeelisJ E Segall
Nov 16, 2002·International Immunopharmacology·A El-MahmoudyT Takewaki
May 22, 2003·Bioorganic & Medicinal Chemistry·Richard B GreenwaldJing Xia
Jun 19, 2003·Drug News & Perspectives·C DerMardirossian, G M Bokoch
Jun 16, 2004·Current Opinion in Cell Biology·Kenji Nakahara, Richard W Carthew
Sep 2, 2004·Journal of Cell Science·Katharina UhlenbrockMohammad Reza Ahmadian
Nov 30, 2005·The International Journal of Biochemistry & Cell Biology·Hala Gali-MuhtasibRegine Schneider-Stock
Oct 20, 2006·Journal of Nanoscience and Nanotechnology·Nazar Noureen GaberYvonne Tze-Fung Tan
Nov 23, 2006·International Journal of Pharmaceutics·R RastogiA K Mishra
Jul 9, 2008·Proceedings of the National Academy of Sciences of the United States of America·Eric A MurphyDavid A Cheresh
Jun 12, 2009·International Journal of Nanomedicine·Vishal GuptaAnshu B Mathur
Oct 15, 2009·Drug Development and Industrial Pharmacy·Lifang WuChunhua Yin
Nov 12, 2009·Life Sciences·Leelavinothan Pari, Chandrasekaran Sankaranarayanan
Nov 17, 2009·Neuron·Sarah K FinebergBeverly L Davidson
Jul 3, 2010·Journal of Experimental & Clinical Cancer Research : CR·Syed H JafriHeather Kleiner-Hancock
Oct 7, 2010·Nutrition and Cancer·Sanjeev BanerjeeRamzi M Mohammad
Mar 26, 2011·Science·Christine L Chaffer, Robert A Weinberg
Oct 19, 2011·Biochemical Pharmacology·Chern Chiuh WooKwong Huat Benny Tan
Feb 22, 2012·The Journal of Biological Chemistry·Dongkyun KimEun-Jung Jin
Aug 10, 2012·Journal of Drug Targeting·Shaheen SultanaMohammed Ali
Nov 24, 2012·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Xiangdong LiJin Hu
Apr 16, 2013·Toxicology and Applied Pharmacology·Israr AhmadNabiha Yusuf
Sep 5, 2013·Drug Discovery Today·Regine Schneider-StockHala U Gali-Muhtasib
Nov 2, 2013·Asian Pacific Journal of Cancer Prevention : APJCP·Xiao-Jin SunChen-Chen Jiang

❮ Previous
Next ❯

Citations

Oct 11, 2015·Biotechnology Advances·Anuradha SubramanianSwaminathan Sethuraman
Aug 18, 2016·Langmuir : the ACS Journal of Surfaces and Colloids·Wentong SunJinchao Zhang
Jan 10, 2018·Advanced Materials·Dedy SeptiadiAlke Petri-Fink
Nov 28, 2017·Natural Product Research·Mir Mohammad Hassan KahilaMohammad Mir-Derikvand
Mar 4, 2018·Journal of Experimental & Clinical Cancer Research : CR·Huiqin ZhuoYongxiang Zhao
May 11, 2018·Oxidative Medicine and Cellular Longevity·Md JakariaDong-Kug Choi
May 10, 2017·IET Nanobiotechnology·Suresh Kumar Vignesh KumarEswaran Hemananthan
Feb 23, 2020·Expert Opinion on Drug Delivery·Charul RathorePoonam Negi
Feb 14, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Binoy MaitiSankar Maiti
Nov 15, 2016·Journal of Experimental & Clinical Cancer Research : CR·Mahmoud AlhosinChristian Bronner
Oct 18, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Maria Camilla BergonziDonatella Degl'Innocenti
Sep 22, 2019·Drug Discovery Today·Md Asaduzzaman KhanJunjiang Fu
Nov 19, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Wamidh H TalibAsma Ismail Mahmod
May 1, 2021·Pharmaceuticals·Belal AlmajaliWisam Nabeel Ibrahim
Aug 6, 2021·International Journal of Nanomedicine·Naif A Al-GabriKhaled A El-Tarabily
Jun 30, 2019·Journal of Agricultural and Food Chemistry·Sudeshna NandiKrishnendu Acharya
Oct 11, 2021·Cellular & Molecular Biology Letters·Mina HomayoonfalBahman Yousefi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Aminoglycosides

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Breast Cancer: Therapeutic Approaches

Several different therapeutic approaches are used to treat breast cancer. These include chemotherapy, hormonal therapy, targeted therapy, and Immunotherapy. Discover the latest research on breast cancer therapeutic approaches here.

Bioinformatics in Biomedicine

Bioinformatics in biomedicine incorporates computer science, biology, chemistry, medicine, mathematics and statistics. Discover the latest research on bioinformatics in biomedicine here.

Breast Invasive Carcinoma

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Cell Migration in Cancer and Metastasis

Migration of cancer cells into surrounding tissue and the vasculature is an initial step in tumor metastasis. Discover the latest research on cell migration in cancer and metastasis here.

Breast Invasive Carcinoma (Keystone)

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here

Aminoglycosides (ASM)

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.