Peiminine inhibits colorectal cancer cell proliferation by inducing apoptosis and autophagy and modulating key metabolic pathways

Oncotarget
Zhi ZhengQiang Shen

Abstract

Peiminine, a compound extracted from the bulbs of Fritillaria thunbergii and traditionally used as a medication in China and other Asian countries, was reported to inhibit colorectal cancer cell proliferation and tumor growth by inducing autophagic cell death. However, its mechanism of anticancer action is not well understood, especially at the metabolic level, which was thought to primarily account for peiminine's efficacy against cancer. Using an established metabolomic profiling platform combining ultra-performance liquid chromatography/tandem mass spectrometry with gas chromatography/mass spectrometry, we identified metabolic alterations in colorectal cancer cell line HCT-116 after peiminine treatment. Among the identified 236 metabolites, the levels of 57 of them were significantly (p < 0.05) different between peiminine-treated and -untreated cells in which 45 metabolites were increased and the other 12 metabolites were decreased. Several of the affected metabolites, including glucose, glutamine, oleate (18:1n9), and lignocerate (24:0), may be involved in regulation of the phosphoinositide 3-kinase/Akt/mammalian target of rapamycin (mTOR) pathway and in the oxidative stress response upon peiminine exposure. Peiminine predo...Continue Reading

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Citations

Aug 3, 2018·Journal of Cellular Physiology·Gang WangXing-Li Fu
Aug 15, 2019·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Jue ZhangLizhu Lin
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Jan 6, 2021·Cells·Crescenzo MassaroCarmela Dell'Aversana
Aug 14, 2021·Frontiers in Molecular Biosciences·Jun RaoZhi Zheng

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Methods Mentioned

BETA
nuclear magnetic resonance
metabolomics profiling
flow cytometry
Confocal microscopy
metabolomic profiling

Software Mentioned

DA
PLS
MultiExperiment Viewer
SPSS
SIMCA
Metabolon

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